Real-world characteristics and outcomes of patients with intermediate high risk acute pulmonary embolism

Ajc Overgaauw; L. J. Meijboom; J. van Es; E. J. Lust; E. H. Serne; Pwb Nanayakkara; Y. M. Smulders; A. J. Kooter; R. W. Sprengers; H. J. de Grooth; R. J. Lely; A. Thijs; A. Vonk Noordegraaf; Lma Heunks; Pwg Elbers; H. J. Bogaard; P. R. Tuinman; E. J. Nossent

doi:https://doi.org/10.52964/AMJA.0936

Real-world characteristics and outcomes of patients with intermediate high risk acute pulmonary embolism

Ajc Overgaauw, L. J. Meijboom, J. van Es, E. J. Lust, E. H. Serne, Pwb Nanayakkara, Y. M. Smulders, A. J. Kooter, R. W. Sprengers, H. J. de Grooth, R. J. Lely, A. Thijs, A. Vonk Noordegraaf, Lma Heunks, Pwg Elbers, H. J. Bogaard, P. R. Tuinman, E. J. Nossent

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

BACKGROUND: Exact benefits of currently recommended close monitoring in intermediate high risk acute pulmonary embolism (PE) patients are unknown. METHODS: This prospective observational cohort study determined clinical characteristics, and disease course of intermediate high risk acute PE patients in an academic hospital setting . Frequency of hemodynamic deterioration, use of rescue reperfusion therapy and PE related mortality, were outcomes of interest. RESULTS: Of 98 intermediate high risk PE patients included for analysis, 81 patients (83%) were closely monitored. Two deteriorated hemodynamically and were treated with rescue reperfusion therapy. One patient survived after this. CONCLUSIONS: In these 98 intermediate high risk PE patients, hemodynamic deterioration occurred in three patients and rescue reperfusion therapy of two closely monitored patients led to survival of one. Underlining the need for better recognition of patients benefitting from and research in the optimal way of close monitoring.

Original language	English
Pages (from-to)	61-66
Number of pages	6
Journal	Acute Medicine
Volume	22
Issue number	2
DOIs	https://doi.org/10.52964/AMJA.0936
Publication status	Published - 2023

Keywords

Critically ill
High care admission
Intermediate high risk
Pulmonary embolism
Risk classification

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Overgaauw, A., Meijboom, L. J., van Es, J., Lust, E. J., Serne, E. H., Nanayakkara, P., Smulders, Y. M., Kooter, A. J., Sprengers, R. W., de Grooth, H. J., Lely, R. J., Thijs, A., Noordegraaf, A. V., Heunks, L., Elbers, P., Bogaard, H. J., Tuinman, P. R., & Nossent, E. J. (2023). Real-world characteristics and outcomes of patients with intermediate high risk acute pulmonary embolism. Acute Medicine, 22(2), 61-66. https://doi.org/10.52964/AMJA.0936

@article{a1d2189dd38a4c06ad7cac84b45956e0,

title = "Real-world characteristics and outcomes of patients with intermediate high risk acute pulmonary embolism",

abstract = "BACKGROUND: Exact benefits of currently recommended close monitoring in intermediate high risk acute pulmonary embolism (PE) patients are unknown. METHODS: This prospective observational cohort study determined clinical characteristics, and disease course of intermediate high risk acute PE patients in an academic hospital setting . Frequency of hemodynamic deterioration, use of rescue reperfusion therapy and PE related mortality, were outcomes of interest. RESULTS: Of 98 intermediate high risk PE patients included for analysis, 81 patients (83%) were closely monitored. Two deteriorated hemodynamically and were treated with rescue reperfusion therapy. One patient survived after this. CONCLUSIONS: In these 98 intermediate high risk PE patients, hemodynamic deterioration occurred in three patients and rescue reperfusion therapy of two closely monitored patients led to survival of one. Underlining the need for better recognition of patients benefitting from and research in the optimal way of close monitoring.",

keywords = "Critically ill, High care admission, Intermediate high risk, Pulmonary embolism, Risk classification",

author = "Ajc Overgaauw and Meijboom, {L. J.} and {van Es}, J. and Lust, {E. J.} and Serne, {E. H.} and Pwb Nanayakkara and Smulders, {Y. M.} and Kooter, {A. J.} and Sprengers, {R. W.} and {de Grooth}, {H. J.} and Lely, {R. J.} and A. Thijs and Noordegraaf, {A. Vonk} and Lma Heunks and Pwg Elbers and Bogaard, {H. J.} and Tuinman, {P. R.} and Nossent, {E. J.}",

note = "Publisher Copyright: {\textcopyright} 2023 Rila Publications Ltd.",

year = "2023",

doi = "https://doi.org/10.52964/AMJA.0936",

language = "English",

volume = "22",

pages = "61--66",

journal = "Acute Medicine",

issn = "1747-4892",

publisher = "Rila Publications Ltd",

number = "2",

}

Overgaauw, A, Meijboom, LJ , van Es, J , Lust, EJ , Serne, EH , Nanayakkara, P , Smulders, YM , Kooter, AJ , Sprengers, RW , de Grooth, HJ , Lely, RJ , Thijs, A , Noordegraaf, AV, Heunks, L, Elbers, P, Bogaard, HJ , Tuinman, PR & Nossent, EJ 2023, 'Real-world characteristics and outcomes of patients with intermediate high risk acute pulmonary embolism', Acute Medicine, vol. 22, no. 2, pp. 61-66. https://doi.org/10.52964/AMJA.0936

TY - JOUR

T1 - Real-world characteristics and outcomes of patients with intermediate high risk acute pulmonary embolism

AU - Overgaauw, Ajc

AU - Meijboom, L. J.

AU - van Es, J.

AU - Lust, E. J.

AU - Serne, E. H.

AU - Nanayakkara, Pwb

AU - Smulders, Y. M.

AU - Kooter, A. J.

AU - Sprengers, R. W.

AU - de Grooth, H. J.

AU - Lely, R. J.

AU - Thijs, A.

AU - Noordegraaf, A. Vonk

AU - Heunks, Lma

AU - Elbers, Pwg

AU - Bogaard, H. J.

AU - Tuinman, P. R.

AU - Nossent, E. J.

PY - 2023

Y1 - 2023

N2 - BACKGROUND: Exact benefits of currently recommended close monitoring in intermediate high risk acute pulmonary embolism (PE) patients are unknown. METHODS: This prospective observational cohort study determined clinical characteristics, and disease course of intermediate high risk acute PE patients in an academic hospital setting . Frequency of hemodynamic deterioration, use of rescue reperfusion therapy and PE related mortality, were outcomes of interest. RESULTS: Of 98 intermediate high risk PE patients included for analysis, 81 patients (83%) were closely monitored. Two deteriorated hemodynamically and were treated with rescue reperfusion therapy. One patient survived after this. CONCLUSIONS: In these 98 intermediate high risk PE patients, hemodynamic deterioration occurred in three patients and rescue reperfusion therapy of two closely monitored patients led to survival of one. Underlining the need for better recognition of patients benefitting from and research in the optimal way of close monitoring.

AB - BACKGROUND: Exact benefits of currently recommended close monitoring in intermediate high risk acute pulmonary embolism (PE) patients are unknown. METHODS: This prospective observational cohort study determined clinical characteristics, and disease course of intermediate high risk acute PE patients in an academic hospital setting . Frequency of hemodynamic deterioration, use of rescue reperfusion therapy and PE related mortality, were outcomes of interest. RESULTS: Of 98 intermediate high risk PE patients included for analysis, 81 patients (83%) were closely monitored. Two deteriorated hemodynamically and were treated with rescue reperfusion therapy. One patient survived after this. CONCLUSIONS: In these 98 intermediate high risk PE patients, hemodynamic deterioration occurred in three patients and rescue reperfusion therapy of two closely monitored patients led to survival of one. Underlining the need for better recognition of patients benefitting from and research in the optimal way of close monitoring.

KW - Critically ill

KW - High care admission

KW - Intermediate high risk

KW - Pulmonary embolism

KW - Risk classification

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U2 - https://doi.org/10.52964/AMJA.0936

DO - https://doi.org/10.52964/AMJA.0936

M3 - Article

C2 - 37306130

SN - 1747-4892

VL - 22

SP - 61

EP - 66

JO - Acute Medicine

JF - Acute Medicine

IS - 2

ER -

Real-world characteristics and outcomes of patients with intermediate high risk acute pulmonary embolism

Abstract

Keywords

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