TY - JOUR
T1 - Reassessment of breakpoints in chromosome 11p15
AU - Henry, I.
AU - van Heyningen, V.
AU - Puech, A.
AU - Scrable, H.
AU - Augereau, P.
AU - Boehm, T.
AU - Rabbitts, T.
AU - Mannens, M.
AU - Rochefort, H.
AU - Jones, C.
PY - 1993
Y1 - 1993
N2 - Specific tumor-associated rearrangements involving the regions 11p13 and 11p15 have been extensively documented. However, cytogenetic definition of the breakpoints occurring at the boundaries of these two regions was not precise enough to correlate with the molecular data. Using probes corresponding to the genes coding for MYOD1, CTSD, LDHA, and RBTN1 and to the anonymous sequence D11S776, we have reassessed the breakpoints of three hybrids (J1.10, BID7, and NYX3.1) and confirmed the localization or more precisely mapped these four genes and the anonymous DNA marker on different subregions of 11pter-->p13, including the smallest region of 11p15.5 duplicated in a patient with Beckwith-Wiedemann syndrome
AB - Specific tumor-associated rearrangements involving the regions 11p13 and 11p15 have been extensively documented. However, cytogenetic definition of the breakpoints occurring at the boundaries of these two regions was not precise enough to correlate with the molecular data. Using probes corresponding to the genes coding for MYOD1, CTSD, LDHA, and RBTN1 and to the anonymous sequence D11S776, we have reassessed the breakpoints of three hybrids (J1.10, BID7, and NYX3.1) and confirmed the localization or more precisely mapped these four genes and the anonymous DNA marker on different subregions of 11pter-->p13, including the smallest region of 11p15.5 duplicated in a patient with Beckwith-Wiedemann syndrome
U2 - https://doi.org/10.1159/000133444
DO - https://doi.org/10.1159/000133444
M3 - Comment/Letter to the editor
C2 - 8422757
SN - 0301-0171
VL - 62
SP - 52
EP - 53
JO - Cytogenetics and Cell Genetics
JF - Cytogenetics and Cell Genetics
IS - 1
ER -