TY - JOUR
T1 - Recent Advances in the Treatment of Immune-Mediated Inflammatory Diseases
AU - Tas, Sander W.
AU - Baeten, Dominique L. P.
PY - 2016
Y1 - 2016
N2 - The treatment of immune-mediated inflammatory diseases (IMIDs) has dramatically improved over the last two decades by the development of a series of targeted biological therapies. This paper focuses on new developments in the treatment of IMIDs. In particular, we discuss how different ways of targeting the same mediators can lead to different efficacy and safety profiles, using B cell targeting as example. In addition, we discuss the emerging field of 'small molecules' that target specifically intracellular processes related to cytokine signaling, cell activation, cell migration, and other processes relevant to tissue inflammation
AB - The treatment of immune-mediated inflammatory diseases (IMIDs) has dramatically improved over the last two decades by the development of a series of targeted biological therapies. This paper focuses on new developments in the treatment of IMIDs. In particular, we discuss how different ways of targeting the same mediators can lead to different efficacy and safety profiles, using B cell targeting as example. In addition, we discuss the emerging field of 'small molecules' that target specifically intracellular processes related to cytokine signaling, cell activation, cell migration, and other processes relevant to tissue inflammation
U2 - https://doi.org/10.1007/978-1-4939-3139-2_9
DO - https://doi.org/10.1007/978-1-4939-3139-2_9
M3 - Article
C2 - 26530799
SN - 1064-3745
VL - 1371
SP - 143
EP - 155
JO - Methods in molecular biology (Clifton, N.J.)
JF - Methods in molecular biology (Clifton, N.J.)
ER -