Recent developments in animal models of drug relapse

Nathan J. Marchant, Xuan Li, Yavin Shaham

Research output: Contribution to journalReview articleAcademicpeer-review

128 Citations (Scopus)


Drug craving and relapse to drug use during abstinence are defining features of addiction. Evidence indicates that drug craving and relapse in humans are often provoked by acute exposure to the self-administered drug, drug-associated cues, or stress. During the last two decades, this clinical scenario has been primarily studied at the preclinical level using the classical reinstatement model. However, a single preclinical model cannot capture the complicated nature of human drug relapse. Therefore, more recently, we and others have developed several other models to study different facets of human drug relapse. In this review, we introduce and discuss recent findings from these other relapse models, including incubation of drug craving, reacquisition and resurgence models, and punishment-based and conflict-based relapse models.

Original languageEnglish
Pages (from-to)675-683
Number of pages9
JournalCurrent Opinion in Neurobiology
Issue number4
Publication statusPublished - 1 Aug 2013

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