TY - JOUR
T1 - Recommendations for a Better Understanding of Sex and Gender in the Neuroscience of Mental Health
AU - Wierenga, Lara Marise
AU - Ruigrok, Amber
AU - Aksnes, Eira Ranheim
AU - Barth, Claudia
AU - Beck, Dani
AU - Burke, Sarah
AU - Crestol, Arielle
AU - van Drunen, Lina
AU - Ferrara, Maria
AU - Galea, Liisa Ann Margaret
AU - Goddings, Anne-Lise
AU - Hausmann, Markus
AU - Homanen, Inka
AU - Klinge, Ineke
AU - de Lange, Ann-Marie
AU - Ouwerkerk, Lieke
AU - van der Miesen, Anna
AU - Proppert, Ricarda
AU - Rieble, Carlotta
AU - Tamnes, Christian Krog
AU - Bos, Marieke Geerte Nynke
N1 - Publisher Copyright: © 2023
PY - 2024/3/1
Y1 - 2024/3/1
N2 - There are prominent sex/gender differences in the prevalence, expression, and life span course of mental health and neurodiverse conditions. However, the underlying sex- and gender-related mechanisms and their interactions are still not fully understood. This lack of knowledge has harmful consequences for those with mental health problems. Therefore, we set up a cocreation session in a 1-week workshop with a multidisciplinary team of 25 researchers, clinicians, and policy makers to identify the main barriers in sex and gender research in the neuroscience of mental health. Based on this work, here we provide recommendations for methodologies, translational research, and stakeholder involvement. These include guidelines for recording, reporting, analysis beyond binary groups, and open science. Improved understanding of sex- and gender-related mechanisms in neuroscience may benefit public health because this is an important step toward precision medicine and may function as an archetype for studying diversity.
AB - There are prominent sex/gender differences in the prevalence, expression, and life span course of mental health and neurodiverse conditions. However, the underlying sex- and gender-related mechanisms and their interactions are still not fully understood. This lack of knowledge has harmful consequences for those with mental health problems. Therefore, we set up a cocreation session in a 1-week workshop with a multidisciplinary team of 25 researchers, clinicians, and policy makers to identify the main barriers in sex and gender research in the neuroscience of mental health. Based on this work, here we provide recommendations for methodologies, translational research, and stakeholder involvement. These include guidelines for recording, reporting, analysis beyond binary groups, and open science. Improved understanding of sex- and gender-related mechanisms in neuroscience may benefit public health because this is an important step toward precision medicine and may function as an archetype for studying diversity.
KW - Brain
KW - Gender
KW - Mental health
KW - Neurodiverse conditions
KW - Sex
UR - http://www.scopus.com/inward/record.url?scp=85183025996&partnerID=8YFLogxK
U2 - 10.1016/j.bpsgos.2023.100283
DO - 10.1016/j.bpsgos.2023.100283
M3 - Review article
C2 - 38312851
SN - 2667-1743
VL - 4
JO - Biological Psychiatry Global Open Science
JF - Biological Psychiatry Global Open Science
IS - 2
M1 - 100283
ER -