Recommendations for Premature Ovarian Insufficiency Surveillance for Female Survivors of Childhood, Adolescent, and Young Adult Cancer: A Report From the International Late Effects of Childhood Cancer Guideline Harmonization Group in Collaboration With the PanCareSurFup Consortium

Wendy van Dorp, Renée L. Mulder, Leontien C. M. Kremer, Melissa M. Hudson, Marry M. van den Heuvel-Eibrink, Marleen H. van den Berg, Jennifer M. Levine, Eline van Dulmen-den Broeder, Natascia di Iorgi, Assunta Albanese, Saro H. Armenian, Smita Bhatia, Louis S. Constine, Andreas Corrias, Rebecca Deans, Uta Dirksen, Clarisa R. Gracia, Lars Hjorth, Leah Kroon, Cornelis B. LambalkWendy Landier, Gill Levitt, Alison Leiper, Lillian Meacham, Alesandro Mussa, Sebastian J. Neggers, Kevin C. Oeffinger, Alberto Revelli, Hanneke M. van Santen, Roderick Skinner, Andrew Toogood, William H. Wallace, Riccardo Haupt

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163 Citations (Scopus)


Female survivors of childhood, adolescent, and young adult (CAYA) cancer who were treated with alkylating agents and/or radiation, with potential exposure of the ovaries, have an increased risk of premature ovarian insufficiency (POI). Clinical practice guidelines can facilitate these survivors' access to optimal treatment of late effects that may improve health and quality of survival; however, surveillance recommendations vary among the existing long-term follow-up guidelines, which impedes the implementation of screening. The present guideline was developed by using an evidence-based approach and summarizes harmonized POI surveillance recommendations for female survivors of CAYA cancer who were diagnosed at age < 25 years. The recommendations were formulated by an international multidisciplinary panel and graded according to the strength of the evidence and the potential benefit gained from early detection and intervention. The harmonized POI surveillance recommendations were developed by using a transparent process and are intended to facilitate care for survivors of CAYA cancer. The harmonized set of POI surveillance recommendations is intended to be scientifically rigorous, to positively influence health outcomes, and to facilitate the care for female survivors of CAYA cancer
Original languageEnglish
Pages (from-to)3440-3450
JournalJournal of clinical oncology
Issue number28
Publication statusPublished - 1 Oct 2016

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