Reconstitution of Semliki forest virus infected mice, induces immune mediated pathological changes in the CNS

J K Fazakerley, S Amor, H E Webb

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47 Citations (Scopus)

Abstract

Reconstitution of Semliki forest virus infected nude mice with spleen cells from their immunocompetent nu/+ litter mates resulted in an abolition of the otherwise persistent brain virus, production of anti-SFV IgG, and development of normally absent brain pathology. The brain pathological changes, including demyelination, seem to be mediated by T cells, and are maximum 14 days after sensitization of the reconstituting spleen cells. Sensitization of the spleen cells 7 days before transfer to the nude mice results in pathological changes advanced by about 8 days, compared to reconstitution with unsensitized cells. The involvement of T cells in the virus-induced pathology is discussed.

Original languageEnglish
Pages (from-to)115-20
Number of pages6
JournalClinical and experimental immunology
Volume52
Issue number1
Publication statusPublished - Apr 1983

Keywords

  • Animals
  • Antibodies, Viral
  • Brain
  • Female
  • Immunoglobulin G
  • Journal Article
  • Male
  • Mice
  • Mice, Nude
  • Research Support, Non-U.S. Gov't
  • Semliki forest virus
  • Spleen
  • Time Factors
  • Togaviridae Infections

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