TY - JOUR
T1 - Reduced fronto-striatal volume in attention-deficit/hyperactivity disorder in two cohorts across the lifespan
AU - Cupertino, Renata Basso
AU - Soheili-Nezhad, Sourena
AU - Grevet, Eugenio Horacio
AU - Bandeira, Cibele Edom
AU - Picon, Felipe Almeida
AU - Tavares, Maria Eduarda de Araujo
AU - Naaijen, Jilly
AU - van Rooij, Daan
AU - Akkermans, Sophie
AU - Vitola, Eduardo Schneider
AU - Zwiers, Marcel P.
AU - Rovaris, Diego Luiz
AU - Hoekstra, Pieter J.
AU - Breda, Vitor
AU - Oosterlaan, Jaap
AU - Hartman, Catharina A.
AU - Beckmann, Christian F.
AU - Buitelaar, Jan K.
AU - Franke, Barbara
AU - Bau, Claiton Henrique Dotto
AU - Sprooten, Emma
PY - 2020
Y1 - 2020
N2 - Attention-Deficit/Hyperactivity Disorder (ADHD) has been associated with altered brain anatomy in neuroimaging studies. However, small and heterogeneous study samples, and the use of region-of-interest and tissue-specific analyses have limited the consistency and replicability of these effects. We used a data-driven multivariate approach to investigate neuroanatomical features associated with ADHD in two independent cohorts: the Dutch NeuroIMAGE cohort (n = 890, 17.2 years) and the Brazilian IMpACT cohort (n = 180, 44.2 years). Using independent component analysis of whole-brain morphometry images, 375 neuroanatomical components were assessed for association with ADHD. In both discovery (corrected-p = 0.0085) and replication (p = 0.032) cohorts, ADHD was associated with reduced volume in frontal lobes, striatum, and their interconnecting white-matter. Current results provide further evidence for the role of the fronto-striatal circuit in ADHD in children, and for the first time show its relevance to ADHD in adults. The fact that the cohorts are from different continents and comprise different age ranges highlights the robustness of the findings.
AB - Attention-Deficit/Hyperactivity Disorder (ADHD) has been associated with altered brain anatomy in neuroimaging studies. However, small and heterogeneous study samples, and the use of region-of-interest and tissue-specific analyses have limited the consistency and replicability of these effects. We used a data-driven multivariate approach to investigate neuroanatomical features associated with ADHD in two independent cohorts: the Dutch NeuroIMAGE cohort (n = 890, 17.2 years) and the Brazilian IMpACT cohort (n = 180, 44.2 years). Using independent component analysis of whole-brain morphometry images, 375 neuroanatomical components were assessed for association with ADHD. In both discovery (corrected-p = 0.0085) and replication (p = 0.032) cohorts, ADHD was associated with reduced volume in frontal lobes, striatum, and their interconnecting white-matter. Current results provide further evidence for the role of the fronto-striatal circuit in ADHD in children, and for the first time show its relevance to ADHD in adults. The fact that the cohorts are from different continents and comprise different age ranges highlights the robustness of the findings.
KW - ADHD
KW - Fronto-striatal
KW - Independent component analysis
KW - Tensor-based morphometry
KW - White matter
UR - http://www.scopus.com/inward/record.url?scp=85090884924&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85090884924&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.nicl.2020.102403
DO - https://doi.org/10.1016/j.nicl.2020.102403
M3 - Article
C2 - 32949876
SN - 2213-1582
VL - 28
SP - 1
EP - 9
JO - NeuroImage: Clinical
JF - NeuroImage: Clinical
M1 - 102403
ER -