Refined physical mapping and genomic structure of the EXTL1 gene

W. Wuyts; N. Spieker; N. van Roy; K. de Boulle; A. de Paepe; P. J. Willems; W. van Hul; R. Versteeg; F. Speleman

doi:https://doi.org/10.1159/000015317

Refined physical mapping and genomic structure of the EXTL1 gene

W. Wuyts, N. Spieker, N. van Roy, K. de Boulle, A. de Paepe, P. J. Willems, W. van Hul, R. Versteeg, F. Speleman

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Research output: Contribution to journal › Article › Academic › peer-review

11 Citations (Scopus)

Abstract

Recently, the EXTL1 gene, a member of the EXT tumor suppressor gene family, has been mapped to 1p36, a chromosome region which is frequently implicated in a wide variety of malignancies, including breast carcinoma, colorectal cancer and neuroblastoma. In this study, we show that the EXTL1 gene is located between the genetic markers D1S511 and D1S234 within 200 kb of the LAP18 gene on chromosome 1p36. 1, a region which has been proposed to harbor a tumor suppressor gene implicated in MYCN-amplified neuroblastomas. In addition, we determined the genomic structure of the EXTL1 gene, revealing that the EXTL1 coding sequence spans 11 exons within a 50-kb region

Original language	English
Pages (from-to)	267-270
Journal	Cytogenetics and Cell Genetics
Volume	86
Issue number	3-4
DOIs	https://doi.org/10.1159/000015317
Publication status	Published - 1999

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https://doi.org/10.1159/000015317

Cite this

@article{31c46170bd64458f9f63a64419c62442,

title = "Refined physical mapping and genomic structure of the EXTL1 gene",

abstract = "Recently, the EXTL1 gene, a member of the EXT tumor suppressor gene family, has been mapped to 1p36, a chromosome region which is frequently implicated in a wide variety of malignancies, including breast carcinoma, colorectal cancer and neuroblastoma. In this study, we show that the EXTL1 gene is located between the genetic markers D1S511 and D1S234 within 200 kb of the LAP18 gene on chromosome 1p36. 1, a region which has been proposed to harbor a tumor suppressor gene implicated in MYCN-amplified neuroblastomas. In addition, we determined the genomic structure of the EXTL1 gene, revealing that the EXTL1 coding sequence spans 11 exons within a 50-kb region",

author = "W. Wuyts and N. Spieker and {van Roy}, N. and {de Boulle}, K. and {de Paepe}, A. and Willems, {P. J.} and {van Hul}, W. and R. Versteeg and F. Speleman",

year = "1999",

doi = "https://doi.org/10.1159/000015317",

language = "English",

volume = "86",

pages = "267--270",

journal = "Cytogenetics and Cell Genetics",

issn = "0301-0171",

publisher = "S. Karger AG",

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TY - JOUR

T1 - Refined physical mapping and genomic structure of the EXTL1 gene

AU - Wuyts, W.

AU - Spieker, N.

AU - van Roy, N.

AU - de Boulle, K.

AU - de Paepe, A.

AU - Willems, P. J.

AU - van Hul, W.

AU - Versteeg, R.

AU - Speleman, F.

PY - 1999

Y1 - 1999

N2 - Recently, the EXTL1 gene, a member of the EXT tumor suppressor gene family, has been mapped to 1p36, a chromosome region which is frequently implicated in a wide variety of malignancies, including breast carcinoma, colorectal cancer and neuroblastoma. In this study, we show that the EXTL1 gene is located between the genetic markers D1S511 and D1S234 within 200 kb of the LAP18 gene on chromosome 1p36. 1, a region which has been proposed to harbor a tumor suppressor gene implicated in MYCN-amplified neuroblastomas. In addition, we determined the genomic structure of the EXTL1 gene, revealing that the EXTL1 coding sequence spans 11 exons within a 50-kb region

AB - Recently, the EXTL1 gene, a member of the EXT tumor suppressor gene family, has been mapped to 1p36, a chromosome region which is frequently implicated in a wide variety of malignancies, including breast carcinoma, colorectal cancer and neuroblastoma. In this study, we show that the EXTL1 gene is located between the genetic markers D1S511 and D1S234 within 200 kb of the LAP18 gene on chromosome 1p36. 1, a region which has been proposed to harbor a tumor suppressor gene implicated in MYCN-amplified neuroblastomas. In addition, we determined the genomic structure of the EXTL1 gene, revealing that the EXTL1 coding sequence spans 11 exons within a 50-kb region

U2 - https://doi.org/10.1159/000015317

DO - https://doi.org/10.1159/000015317

M3 - Article

C2 - 10575224

SN - 0301-0171

VL - 86

SP - 267

EP - 270

JO - Cytogenetics and Cell Genetics

JF - Cytogenetics and Cell Genetics

IS - 3-4

ER -