Regional sublocalization of the human CD69 gene to chromosome bands 12p12.3-p13.2, the predicted region of the human natural killer cell gene complex

S. Schnittger; J. [=Jörg] Hamann; C. Dannenberg; H. Fiebig; M. Strauss; C. Fonatsch

doi:https://doi.org/10.1002/eji.1830231051

Regional sublocalization of the human CD69 gene to chromosome bands 12p12.3-p13.2, the predicted region of the human natural killer cell gene complex

S. Schnittger, J. [=Jörg] Hamann, C. Dannenberg, H. Fiebig, M. Strauss, C. Fonatsch

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Research output: Contribution to journal › Comment/Letter to the editor › Academic

23 Citations (Scopus)

Abstract

The early activation antigen CD69 is a member of a supergene family of type II integral membrane proteins with a C-type lectin domain. In recent reports the genes encoding the natural killer (NK) cell-related molecules of this supergene family, NKR-P1, NK1.1 and Ly-49, were shown to be clustered in a chromosomal region in mouse, termed the NK gene complex. The human homologue of this complex is likely to reside on chromosome 12 near the PRP locus (12p13.2). By analyzing T cell hybrids, the CD69 gene was previously mapped to human chromosome 12. Here we report the regional sublocalization of the human CD69 gene to chromosome bands 12p12.3-p13.2, suggesting that CD69 belongs to one linkage group together with different cell surface molecules on NK cells

Original language	English
Pages (from-to)	2711-2713
Journal	European journal of immunology
Volume	23
Issue number	10
DOIs	https://doi.org/10.1002/eji.1830231051
Publication status	Published - 1993

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https://doi.org/10.1002/eji.1830231051

Cite this

@article{8c72c36483b34932acaa3bc4d55cf966,

title = "Regional sublocalization of the human CD69 gene to chromosome bands 12p12.3-p13.2, the predicted region of the human natural killer cell gene complex",

abstract = "The early activation antigen CD69 is a member of a supergene family of type II integral membrane proteins with a C-type lectin domain. In recent reports the genes encoding the natural killer (NK) cell-related molecules of this supergene family, NKR-P1, NK1.1 and Ly-49, were shown to be clustered in a chromosomal region in mouse, termed the NK gene complex. The human homologue of this complex is likely to reside on chromosome 12 near the PRP locus (12p13.2). By analyzing T cell hybrids, the CD69 gene was previously mapped to human chromosome 12. Here we report the regional sublocalization of the human CD69 gene to chromosome bands 12p12.3-p13.2, suggesting that CD69 belongs to one linkage group together with different cell surface molecules on NK cells",

author = "S. Schnittger and Hamann, {J. [=J{\"o}rg]} and C. Dannenberg and H. Fiebig and M. Strauss and C. Fonatsch",

year = "1993",

doi = "https://doi.org/10.1002/eji.1830231051",

language = "English",

volume = "23",

pages = "2711--2713",

journal = "European journal of immunology",

issn = "0014-2980",

publisher = "Wiley-VCH Verlag",

number = "10",

}

Regional sublocalization of the human CD69 gene to chromosome bands 12p12.3-p13.2, the predicted region of the human natural killer cell gene complex. / Schnittger, S.; Hamann, J. [=Jörg]; Dannenberg, C. et al.
In: European journal of immunology, Vol. 23, No. 10, 1993, p. 2711-2713.

Research output: Contribution to journal › Comment/Letter to the editor › Academic

TY - JOUR

T1 - Regional sublocalization of the human CD69 gene to chromosome bands 12p12.3-p13.2, the predicted region of the human natural killer cell gene complex

AU - Schnittger, S.

AU - Hamann, J. [=Jörg]

AU - Dannenberg, C.

AU - Fiebig, H.

AU - Strauss, M.

AU - Fonatsch, C.

PY - 1993

Y1 - 1993

N2 - The early activation antigen CD69 is a member of a supergene family of type II integral membrane proteins with a C-type lectin domain. In recent reports the genes encoding the natural killer (NK) cell-related molecules of this supergene family, NKR-P1, NK1.1 and Ly-49, were shown to be clustered in a chromosomal region in mouse, termed the NK gene complex. The human homologue of this complex is likely to reside on chromosome 12 near the PRP locus (12p13.2). By analyzing T cell hybrids, the CD69 gene was previously mapped to human chromosome 12. Here we report the regional sublocalization of the human CD69 gene to chromosome bands 12p12.3-p13.2, suggesting that CD69 belongs to one linkage group together with different cell surface molecules on NK cells

AB - The early activation antigen CD69 is a member of a supergene family of type II integral membrane proteins with a C-type lectin domain. In recent reports the genes encoding the natural killer (NK) cell-related molecules of this supergene family, NKR-P1, NK1.1 and Ly-49, were shown to be clustered in a chromosomal region in mouse, termed the NK gene complex. The human homologue of this complex is likely to reside on chromosome 12 near the PRP locus (12p13.2). By analyzing T cell hybrids, the CD69 gene was previously mapped to human chromosome 12. Here we report the regional sublocalization of the human CD69 gene to chromosome bands 12p12.3-p13.2, suggesting that CD69 belongs to one linkage group together with different cell surface molecules on NK cells

U2 - https://doi.org/10.1002/eji.1830231051

DO - https://doi.org/10.1002/eji.1830231051

M3 - Comment/Letter to the editor

C2 - 8405070

SN - 0014-2980

VL - 23

SP - 2711

EP - 2713

JO - European journal of immunology

JF - European journal of immunology

IS - 10

ER -