TY - JOUR
T1 - Regulation of cholesterol homeostasis
AU - van der Wulp, Mariëtte Y. M.
AU - Verkade, Henkjan J.
AU - Groen, Albert K.
PY - 2013
Y1 - 2013
N2 - Hypercholesterolemia is an important risk factor for cardiovascular disease. It is caused by a disturbed balance between cholesterol secretion into the blood versus uptake. The pathways involved are regulated via a complex interplay of enzymes, transport proteins, transcription factors and non-coding RNA's. The last two decades insight into underlying mechanisms has increased vastly but there are still a lot of unknowns, particularly regarding intracellular cholesterol transport. After decades of concentration on the liver, in recent years the intestine has come into focus as an important control point in cholesterol homeostasis. This review will discuss current knowledge of cholesterol physiology, with emphasis on cholesterol absorption, cholesterol synthesis and fecal excretion, and new (possible) therapeutic options for hypercholesterolemia. (C) 2012 Elsevier Ireland Ltd. All rights reserved
AB - Hypercholesterolemia is an important risk factor for cardiovascular disease. It is caused by a disturbed balance between cholesterol secretion into the blood versus uptake. The pathways involved are regulated via a complex interplay of enzymes, transport proteins, transcription factors and non-coding RNA's. The last two decades insight into underlying mechanisms has increased vastly but there are still a lot of unknowns, particularly regarding intracellular cholesterol transport. After decades of concentration on the liver, in recent years the intestine has come into focus as an important control point in cholesterol homeostasis. This review will discuss current knowledge of cholesterol physiology, with emphasis on cholesterol absorption, cholesterol synthesis and fecal excretion, and new (possible) therapeutic options for hypercholesterolemia. (C) 2012 Elsevier Ireland Ltd. All rights reserved
U2 - https://doi.org/10.1016/j.mce.2012.06.007
DO - https://doi.org/10.1016/j.mce.2012.06.007
M3 - Review article
C2 - 22721653
SN - 0303-7207
VL - 368
SP - 1
EP - 16
JO - Molecular and cellular endocrinology
JF - Molecular and cellular endocrinology
IS - 1-2
ER -