Abstract
Homeostatic control of T cells involves tight regulation of effector T cells to prevent excessive activation that can cause tissue damage and autoimmunity. Little is known, however, about whether antigen-presenting cells (APCs) are also involved in maintaining immune system homeostasis once effector T cells are stimulated. Here we found that immature APCs downregulated effector T cell function by a mechanism involving the C-type lectin MGL expressed by APCs. Glycosylation-dependent interactions of MGL with CD45 on effector T cells negatively regulated T cell receptor-mediated signaling and T cell-dependent cytokine responses, which in turn decreased T cell proliferation and increased T cell death. Thus, regulation of effector T cells by MGL expressed on APCs may provide a target for regulating chronic inflammatory and autoimmune diseases.
Original language | English |
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Pages (from-to) | 1200-8 |
Number of pages | 9 |
Journal | Nature immunology |
Volume | 7 |
Issue number | 11 |
DOIs | |
Publication status | Published - Nov 2006 |
Keywords
- Animals
- Antigen-Presenting Cells/immunology
- CD4-Positive T-Lymphocytes/immunology
- CD8-Positive T-Lymphocytes/immunology
- CHO Cells
- Cells, Cultured
- Clone Cells
- Cricetinae
- Cricetulus
- Cytokines/metabolism
- Humans
- Jurkat Cells
- Lectins, C-Type/metabolism
- Leukocyte Common Antigens/metabolism
- Signal Transduction/immunology