TY - JOUR
T1 - Regulation of TRPV5 and TRPV6 by associated proteins
AU - van de Graaf, Stan F. J.
AU - Hoenderop, Joost G. J.
AU - Bindels, René J. M.
PY - 2006
Y1 - 2006
N2 - The epithelial Ca2+ channels TRPV5 and TRPV6 are the most Ca2+-selective members of the TRP channel superfamily. These channels are the prime target for hormonal control of the active Ca2+ flux from the urine space or intestinal lumen to the blood compartment. Insight into their regulation is, therefore, pivotal in our understanding of the (patho)physiology of Ca2+ homeostasis. The recent elucidation of TRPV5/6-associated proteins has provided new insight into the molecular mechanisms underlying the regulation of these channels. In this review, we describe the various means of TRPV5/6 regulation, the role of channel-associated proteins herein, and the relationship between both processes
AB - The epithelial Ca2+ channels TRPV5 and TRPV6 are the most Ca2+-selective members of the TRP channel superfamily. These channels are the prime target for hormonal control of the active Ca2+ flux from the urine space or intestinal lumen to the blood compartment. Insight into their regulation is, therefore, pivotal in our understanding of the (patho)physiology of Ca2+ homeostasis. The recent elucidation of TRPV5/6-associated proteins has provided new insight into the molecular mechanisms underlying the regulation of these channels. In this review, we describe the various means of TRPV5/6 regulation, the role of channel-associated proteins herein, and the relationship between both processes
U2 - https://doi.org/10.1152/ajprenal.00443.2005
DO - https://doi.org/10.1152/ajprenal.00443.2005
M3 - Review article
C2 - 16682485
SN - 0363-6127
VL - 290
SP - F1295-F1302
JO - American Journal of Physiology. Renal Physiology
JF - American Journal of Physiology. Renal Physiology
IS - 6
ER -