Regulatory rnas controlling vascular (DYS)function by affecting TGF-β family signalling

Kondababu Kurakula, Marie Jose Goumans, Peter Ten Dijke

Research output: Contribution to journalReview articleAcademicpeer-review

12 Citations (Scopus)

Abstract

Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide. Over the last few years, microRNAs (miRNAs) have emerged as master regulators of gene expression in cardiovascular biology and disease. miRNAs are small endogenous non-coding RNAs that usually bind to 3′ untranslated region (UTR) of their target mRNAs and inhibit mRNA stability or translation of their target genes. miRNAs play a dynamic role in the pathophysiology of many CVDs through their effects on target mRNAs in vascular cells. Recently, numerous miRNAs have been implicated in the regulation of the transforming growth factor-β (TGF-β)/bone morphogenetic protein (BMP) signalling pathway which plays crucial roles in diverse biological processes, and is involved in pathogenesis of many diseases including CVD. This review gives an overview of current literature on the role of miRNAs targeting TGF-β/BMP signalling in vascular cells, including endothelial cells and smooth muscle cells. We also provide insight into how this miRNA-mediated regulation of TGF-β/BMP signalling might be used to harness CVD.

Original languageEnglish
Pages (from-to)832-850
Number of pages19
JournalEXCLI Journal
Volume14
DOIs
Publication statusPublished - 10 Jul 2015

Keywords

  • Bone morphogenetic protein
  • Cardiovascular disease
  • Endothelial cells
  • MicroRNA
  • Smooth muscle cells
  • Transforming growth factor-β

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