Abstract
STUDY OBJECTIVES: To analyse the relation between the longitudinal development of total serum cholesterol (TC), high density lipoprotein cholesterol (HDL), and the TC/ HDL ratio and the longitudinal development of the biological parameters body fatness (SSF), lean body mass (LBM), and cardiopulmonary fitness (VO2-max). The relations were analysed with generalised estimating equations (GEE).
SETTING: The relations were investigated with data from the Amsterdam growth and health study, a longitudinal study in which six measurements were carried out within a period of 15 years.
PARTICIPANTS: Altogether 98 females and 84 males aged 13 years at the start of the study.
MAIN RESULTS: Adjusted for lifestyle and other biological parameters, the longitudinal development of TC was inversely related to the development of LBM (standardised regression coefficient beta = -0.27; p < or = 0.01) and positively to SSF (beta males = 0.32; p < or = 0.01 and beta females = 0.15; p < or = 0.01). HDL was inversely related to LBM (beta = -0.26; p < or = 0.01) and positively to VO2-max (beta = 0.08; p < or = 0.05). The TC/HDL ratio was positively related to SSF (beta males = 0.39; p < or = 0.01 and beta females = 0.13; p < or = 0.01) and inversely to VO2-max (beta = -0.09; p < or = 0.05).
CONCLUSIONS: The longitudinal analyses showed that body fatness was related to a high risk profile with respect to hypercholesterolaemia, and cardiopulmonary fitness to a low risk profile. Furthermore, it was shown that using body mass index as an indicator of body fatness in relation to lipoprotein values, has some important drawbacks.
Original language | English |
---|---|
Pages (from-to) | 505-11 |
Number of pages | 7 |
Journal | Journal of Epidemiology and Community Health |
Volume | 50 |
Issue number | 5 |
Publication status | Published - Oct 1996 |
Keywords
- Adolescent
- Aging/blood
- Analysis of Variance
- Body Mass Index
- Body Weight/physiology
- Cholesterol, HDL/blood
- Cholesterol/blood
- Female
- Humans
- Longitudinal Studies
- Male
- Oxygen Consumption/physiology
- Skinfold Thickness