TY - JOUR
T1 - Relationship between temporal sequence of right ventricular deformation and right ventricular performance in patients with corrected tetralogy of Fallot
AU - van der Hulst, Annelies E.
AU - Roest, Arno A. W.
AU - Delgado, Victoria
AU - Holman, Eduard R.
AU - de Roos, Albert
AU - Blom, Nico A.
AU - Bax, Jeroen J.
PY - 2011
Y1 - 2011
N2 - Right ventricular (RV) dysfunction is common in patients with corrected tetralogy of Fallot (cToF). Abnormalities in the temporal pattern of RV mechanical activation have been observed in patients with cToF, but the relationship with RV performance remains unclear. This study characterises RV performance and the temporal sequence of RV deformation in patients with cToF and healthy controls. 37 patients with cToF were compared with 18 controls. Using two-dimensional speckle tracking analysis, global RV strain was assessed. In addition, time to peak strain and the time difference between RV inlet and RV outlet (RV time delay) was assessed. The relation between RV performance and RV time delay was assessed with linear regression analysis. Results RV strain was reduced in patients compared with controls (-20.9 ± 4.3% vs -30.7 ± 3.4%, p <0.001). Time to peak strain at the RV inlet showed no differences between patients with cToF and controls (406 ± 55 ms vs 405 ± 67 ms, p=0.429), whereas time to peak strain at the RV outlet was significantly delayed in patients with cToF (339 ± 75 ms vs 262 ± 85 ms, p=0.003). Consequently, RV time delay was significantly shorter in patients with cToF than in controls (66 ± 48 ms vs 143 ± 53 ms, p <0.001). A close relation between RV time delay and RV strain was observed (r=-0.70, p <0.001). In patients with cToF, RV outlet deformation is delayed, causing a reduction in RV time delay which is significantly related to impairment in RV performance
AB - Right ventricular (RV) dysfunction is common in patients with corrected tetralogy of Fallot (cToF). Abnormalities in the temporal pattern of RV mechanical activation have been observed in patients with cToF, but the relationship with RV performance remains unclear. This study characterises RV performance and the temporal sequence of RV deformation in patients with cToF and healthy controls. 37 patients with cToF were compared with 18 controls. Using two-dimensional speckle tracking analysis, global RV strain was assessed. In addition, time to peak strain and the time difference between RV inlet and RV outlet (RV time delay) was assessed. The relation between RV performance and RV time delay was assessed with linear regression analysis. Results RV strain was reduced in patients compared with controls (-20.9 ± 4.3% vs -30.7 ± 3.4%, p <0.001). Time to peak strain at the RV inlet showed no differences between patients with cToF and controls (406 ± 55 ms vs 405 ± 67 ms, p=0.429), whereas time to peak strain at the RV outlet was significantly delayed in patients with cToF (339 ± 75 ms vs 262 ± 85 ms, p=0.003). Consequently, RV time delay was significantly shorter in patients with cToF than in controls (66 ± 48 ms vs 143 ± 53 ms, p <0.001). A close relation between RV time delay and RV strain was observed (r=-0.70, p <0.001). In patients with cToF, RV outlet deformation is delayed, causing a reduction in RV time delay which is significantly related to impairment in RV performance
U2 - https://doi.org/10.1136/hrt.2010.199919
DO - https://doi.org/10.1136/hrt.2010.199919
M3 - Article
C2 - 21138862
SN - 1355-6037
VL - 97
SP - 231
EP - 236
JO - Heart (British Cardiac Society)
JF - Heart (British Cardiac Society)
IS - 3
ER -