Relative bioavailability of a new oral form of cyclosporin A in patients with rheumatoid arthritis

B. E. van den Borne; R. B. Landewé; H. S. Goei The; H. Mattie; F. C. Breedveld; B. A. Dijkmans

Relative bioavailability of a new oral form of cyclosporin A in patients with rheumatoid arthritis

B. E. van den Borne, R. B. Landewé, H. S. Goei The, H. Mattie, F. C. Breedveld, B. A. Dijkmans

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Research output: Contribution to journal › Comment/Letter to the editor › Academic

24 Citations (Scopus)

Abstract

The relative bioavailability of cyclosporin A (CsA) from a new microemulsion oral formulation (NEO) and the currently used soft gelatine capsule (SGC) was determined at steady state in 12 patients with rheumatoid arthritis. The AUC(0,12 h) values of cyclosporin A were significantly greater after NEO than SGC (2873 +/- 848 ng ml-1 h (mean +/- s.d.) vs 2355 +/- 1128 ng ml-1 h; P = 0.02, 95% CI (confidence interval of the difference: 81 to 955 ng ml-1 h). Cmax values were significantly higher after NEO than after SGC (811 +/- 244 ng ml-1 vs 495 +/- 291 ng ml-1, P <0.0001, 95% CI of the difference: 209 to 422 ng ml-1)

Original language	English
Pages (from-to)	172-175
Journal	British journal of clinical pharmacology
Volume	39
Issue number	2
Publication status	Published - 1995

Cite this

@article{521052c345da4357a8091174e639018f,

title = "Relative bioavailability of a new oral form of cyclosporin A in patients with rheumatoid arthritis",

abstract = "The relative bioavailability of cyclosporin A (CsA) from a new microemulsion oral formulation (NEO) and the currently used soft gelatine capsule (SGC) was determined at steady state in 12 patients with rheumatoid arthritis. The AUC(0,12 h) values of cyclosporin A were significantly greater after NEO than SGC (2873 +/- 848 ng ml-1 h (mean +/- s.d.) vs 2355 +/- 1128 ng ml-1 h; P = 0.02, 95% CI (confidence interval of the difference: 81 to 955 ng ml-1 h). Cmax values were significantly higher after NEO than after SGC (811 +/- 244 ng ml-1 vs 495 +/- 291 ng ml-1, P <0.0001, 95% CI of the difference: 209 to 422 ng ml-1)",

author = "{van den Borne}, {B. E.} and Landew{\'e}, {R. B.} and {Goei The}, {H. S.} and H. Mattie and Breedveld, {F. C.} and Dijkmans, {B. A.}",

year = "1995",

language = "English",

volume = "39",

pages = "172--175",

journal = "British journal of clinical pharmacology",

issn = "0306-5251",

publisher = "Wiley-Blackwell",

number = "2",

}

TY - JOUR

T1 - Relative bioavailability of a new oral form of cyclosporin A in patients with rheumatoid arthritis

AU - van den Borne, B. E.

AU - Landewé, R. B.

AU - Goei The, H. S.

AU - Mattie, H.

AU - Breedveld, F. C.

AU - Dijkmans, B. A.

PY - 1995

Y1 - 1995

N2 - The relative bioavailability of cyclosporin A (CsA) from a new microemulsion oral formulation (NEO) and the currently used soft gelatine capsule (SGC) was determined at steady state in 12 patients with rheumatoid arthritis. The AUC(0,12 h) values of cyclosporin A were significantly greater after NEO than SGC (2873 +/- 848 ng ml-1 h (mean +/- s.d.) vs 2355 +/- 1128 ng ml-1 h; P = 0.02, 95% CI (confidence interval of the difference: 81 to 955 ng ml-1 h). Cmax values were significantly higher after NEO than after SGC (811 +/- 244 ng ml-1 vs 495 +/- 291 ng ml-1, P <0.0001, 95% CI of the difference: 209 to 422 ng ml-1)

AB - The relative bioavailability of cyclosporin A (CsA) from a new microemulsion oral formulation (NEO) and the currently used soft gelatine capsule (SGC) was determined at steady state in 12 patients with rheumatoid arthritis. The AUC(0,12 h) values of cyclosporin A were significantly greater after NEO than SGC (2873 +/- 848 ng ml-1 h (mean +/- s.d.) vs 2355 +/- 1128 ng ml-1 h; P = 0.02, 95% CI (confidence interval of the difference: 81 to 955 ng ml-1 h). Cmax values were significantly higher after NEO than after SGC (811 +/- 244 ng ml-1 vs 495 +/- 291 ng ml-1, P <0.0001, 95% CI of the difference: 209 to 422 ng ml-1)

M3 - Comment/Letter to the editor

C2 - 7742156

SN - 0306-5251

VL - 39

SP - 172

EP - 175

JO - British journal of clinical pharmacology

JF - British journal of clinical pharmacology

IS - 2

ER -