Relative insufficiency of the fibrinolytic system in disseminated intravascular coagulation

Marcel Levi; Tom Van Der Poll; Evert De Jonge; Hugo Ten Cate

doi:https://doi.org/10.1023/A:1009847432281

Relative insufficiency of the fibrinolytic system in disseminated intravascular coagulation

Marcel Levi, Tom Van Der Poll, Evert De Jonge, Hugo Ten Cate

Research output: Contribution to journal › Article › Academic › peer-review

4 Citations (Scopus)

Abstract

Experimental and clinical observations indicate that the systemic deposition of fibrin in disseminated intravascular coagulation (DIC) is insufficiently counteracted by endogenous fibrinolysis. In fact, a marked suppression of fibrinolytic activity, due to elevated levels of PAI-1, can be observed in experimental DIC as well as in patients with DIC from various causes. Relatively impaired plasmin generation is in dysbalance with enhanced thrombin generation and may contribute to the occurrence of systemic microvascular thrombosis and subsequent organ dysfunction.

Original language	English
Pages (from-to)	119-124
Number of pages	6
Journal	Sepsis
Volume	3
Issue number	2
DOIs	https://doi.org/10.1023/A:1009847432281
Publication status	Published - 1999

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title = "Relative insufficiency of the fibrinolytic system in disseminated intravascular coagulation",

abstract = "Experimental and clinical observations indicate that the systemic deposition of fibrin in disseminated intravascular coagulation (DIC) is insufficiently counteracted by endogenous fibrinolysis. In fact, a marked suppression of fibrinolytic activity, due to elevated levels of PAI-1, can be observed in experimental DIC as well as in patients with DIC from various causes. Relatively impaired plasmin generation is in dysbalance with enhanced thrombin generation and may contribute to the occurrence of systemic microvascular thrombosis and subsequent organ dysfunction.",

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AU - De Jonge, Evert

AU - Ten Cate, Hugo

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AB - Experimental and clinical observations indicate that the systemic deposition of fibrin in disseminated intravascular coagulation (DIC) is insufficiently counteracted by endogenous fibrinolysis. In fact, a marked suppression of fibrinolytic activity, due to elevated levels of PAI-1, can be observed in experimental DIC as well as in patients with DIC from various causes. Relatively impaired plasmin generation is in dysbalance with enhanced thrombin generation and may contribute to the occurrence of systemic microvascular thrombosis and subsequent organ dysfunction.

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Relative insufficiency of the fibrinolytic system in disseminated intravascular coagulation

Abstract

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