TY - JOUR
T1 - Relative position of the atrioventricular canal determines the electrical activation of developing reptile ventricles
AU - Gregorovicova, Martina
AU - Sedmera, David
AU - Jensen, Bjarke
PY - 2018
Y1 - 2018
N2 - Squamate reptiles appear to lack the specialized His-Purkinje system that enables the cardiac ventricle to be activated from apex to base as in mammals and birds. Instead, activation may simply spread from where the atrioventricular canal connects to the base. Gja5, which encodes Cx40, which allows fast impulse propagation, was expressed throughout the ventricles of developing anole lizards. Activation was optically recorded in developing corn snake and central bearded dragon. Early embryonic ventricles were broad in shape, and activation propagated from the base to the right. Elongated ventricles of later stages were activated from base to apex. Before hatching of the snake, the ventricle developed a cranial extension on the left and activation propagated from the base to the caudal apex and the cranial extension. In squamate reptiles, the pattern of electrical activation of the cardiac ventricle is dependent on the position of the atrioventricular canal and the shape of the ventricle.
AB - Squamate reptiles appear to lack the specialized His-Purkinje system that enables the cardiac ventricle to be activated from apex to base as in mammals and birds. Instead, activation may simply spread from where the atrioventricular canal connects to the base. Gja5, which encodes Cx40, which allows fast impulse propagation, was expressed throughout the ventricles of developing anole lizards. Activation was optically recorded in developing corn snake and central bearded dragon. Early embryonic ventricles were broad in shape, and activation propagated from the base to the right. Elongated ventricles of later stages were activated from base to apex. Before hatching of the snake, the ventricle developed a cranial extension on the left and activation propagated from the base to the caudal apex and the cranial extension. In squamate reptiles, the pattern of electrical activation of the cardiac ventricle is dependent on the position of the atrioventricular canal and the shape of the ventricle.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85048312946&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/29674379
U2 - https://doi.org/10.1242/jeb.178400
DO - https://doi.org/10.1242/jeb.178400
M3 - Article
C2 - 29674379
SN - 0022-0949
VL - 221
JO - Journal of experimental biology
JF - Journal of experimental biology
IS - 11
M1 - 178400
ER -