Relevance of Retinal Thickness Changes in the OCT Inner and Outer Rings to Predict Progression to Clinical Macular Edema: An Attempt of Composite Grading of Macular Edema

Stela Vujosevic; Monica Varano; Catherine Egan; Sobha Sivaprasad; Geeta Menon; Ali Erginay; Frank D. Verbraak; Henrik Lund-Andersen; Jose P. Martinez; Ignasi Jürgens; Erica Smets; Caroline Coriat; Peter Wiedemann; Victor Ágoas; Giuseppe Querques; Frank G. Holz; Sandrina Nunes; Dalila Alves; Catarina Neves; Torcato Santos; Luisa Ribeiro; Francesco Bandello; Amparo Navea Tejerina; José Cunha-Vaz

doi:https://doi.org/10.1159/000441110

Relevance of Retinal Thickness Changes in the OCT Inner and Outer Rings to Predict Progression to Clinical Macular Edema: An Attempt of Composite Grading of Macular Edema

Stela Vujosevic, Monica Varano, Catherine Egan, Sobha Sivaprasad, Geeta Menon, Ali Erginay, Frank D. Verbraak, Henrik Lund-Andersen, Jose P. Martinez, Ignasi Jürgens, Erica Smets, Caroline Coriat, Peter Wiedemann, Victor Ágoas, Giuseppe Querques, Frank G. Holz, Sandrina Nunes, Dalila Alves, Catarina Neves, Torcato SantosLuisa Ribeiro, Francesco Bandello, Amparo Navea Tejerina, José Cunha-Vaz

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

To characterize the relevance of macular thickness changes in the inner and outer rings in the progression of macular edema in eyes/patients with diabetes type 2. A total of 374 type 2 diabetic patients with mild nonproliferative diabetic retinopathy (ETDRS levels 20-35) were included in a 12-month prospective observational study to identify retinopathy progression. Retinal thickness analyses were performed in 194 eyes/patients using Cirrus SD- OCT and 166 eyes/patients using Spectralis SD-OCT. The DRCR.net classification of subclinical and clinical macular edema was used. A composite grading of macular edema is proposed in this study. A total of 317 eyes/patients completed the study. SD-OCT identified clinical macular edema in 24 eyes/patients (6.7%) and subclinical macular edema in 104 eyes/patients (28.9%) at baseline. Increased thickness of the central subfield is the best predictor for the development of clinical macular edema, with 85.7% sensitivity and 71.9% specificity (OR: 2.57, 95% CI: 0.82-7.99). However, the involvement of the inner and outer rings is a cumulative predictor of progression to clinical macular edema (OR: 8.69, 95% CI: 2.85-26.52). A composite OCT grading of macular edema taking into account the retinal thickness changes in the inner and outer macular rings offers a simple way to characterize macular edema, with added clinical value

Original language	English
Pages (from-to)	19-25
Journal	Ophthalmic research
Volume	55
Issue number	1
DOIs	https://doi.org/10.1159/000441110
Publication status	Published - 2016

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https://doi.org/10.1159/000441110

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Vujosevic, S., Varano, M., Egan, C., Sivaprasad, S., Menon, G., Erginay, A., Verbraak, F. D., Lund-Andersen, H., Martinez, J. P., Jürgens, I., Smets, E., Coriat, C., Wiedemann, P., Ágoas, V., Querques, G., Holz, F. G., Nunes, S., Alves, D., Neves, C., ... Cunha-Vaz, J. (2016). Relevance of Retinal Thickness Changes in the OCT Inner and Outer Rings to Predict Progression to Clinical Macular Edema: An Attempt of Composite Grading of Macular Edema. Ophthalmic research, 55(1), 19-25. https://doi.org/10.1159/000441110

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title = "Relevance of Retinal Thickness Changes in the OCT Inner and Outer Rings to Predict Progression to Clinical Macular Edema: An Attempt of Composite Grading of Macular Edema",

abstract = "To characterize the relevance of macular thickness changes in the inner and outer rings in the progression of macular edema in eyes/patients with diabetes type 2. A total of 374 type 2 diabetic patients with mild nonproliferative diabetic retinopathy (ETDRS levels 20-35) were included in a 12-month prospective observational study to identify retinopathy progression. Retinal thickness analyses were performed in 194 eyes/patients using Cirrus SD- OCT and 166 eyes/patients using Spectralis SD-OCT. The DRCR.net classification of subclinical and clinical macular edema was used. A composite grading of macular edema is proposed in this study. A total of 317 eyes/patients completed the study. SD-OCT identified clinical macular edema in 24 eyes/patients (6.7%) and subclinical macular edema in 104 eyes/patients (28.9%) at baseline. Increased thickness of the central subfield is the best predictor for the development of clinical macular edema, with 85.7% sensitivity and 71.9% specificity (OR: 2.57, 95% CI: 0.82-7.99). However, the involvement of the inner and outer rings is a cumulative predictor of progression to clinical macular edema (OR: 8.69, 95% CI: 2.85-26.52). A composite OCT grading of macular edema taking into account the retinal thickness changes in the inner and outer macular rings offers a simple way to characterize macular edema, with added clinical value",

author = "Stela Vujosevic and Monica Varano and Catherine Egan and Sobha Sivaprasad and Geeta Menon and Ali Erginay and Verbraak, {Frank D.} and Henrik Lund-Andersen and Martinez, {Jose P.} and Ignasi J{\"u}rgens and Erica Smets and Caroline Coriat and Peter Wiedemann and Victor {\'A}goas and Giuseppe Querques and Holz, {Frank G.} and Sandrina Nunes and Dalila Alves and Catarina Neves and Torcato Santos and Luisa Ribeiro and Francesco Bandello and Tejerina, {Amparo Navea} and Jos{\'e} Cunha-Vaz",

year = "2016",

doi = "https://doi.org/10.1159/000441110",

language = "English",

volume = "55",

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journal = "Ophthalmic research",

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Vujosevic, S, Varano, M, Egan, C, Sivaprasad, S, Menon, G, Erginay, A, Verbraak, FD, Lund-Andersen, H, Martinez, JP, Jürgens, I, Smets, E, Coriat, C, Wiedemann, P, Ágoas, V, Querques, G, Holz, FG, Nunes, S, Alves, D, Neves, C, Santos, T, Ribeiro, L, Bandello, F, Tejerina, AN & Cunha-Vaz, J 2016, 'Relevance of Retinal Thickness Changes in the OCT Inner and Outer Rings to Predict Progression to Clinical Macular Edema: An Attempt of Composite Grading of Macular Edema', Ophthalmic research, vol. 55, no. 1, pp. 19-25. https://doi.org/10.1159/000441110

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T1 - Relevance of Retinal Thickness Changes in the OCT Inner and Outer Rings to Predict Progression to Clinical Macular Edema: An Attempt of Composite Grading of Macular Edema

AU - Vujosevic, Stela

AU - Varano, Monica

AU - Egan, Catherine

AU - Sivaprasad, Sobha

AU - Menon, Geeta

AU - Erginay, Ali

AU - Verbraak, Frank D.

AU - Lund-Andersen, Henrik

AU - Martinez, Jose P.

AU - Jürgens, Ignasi

AU - Smets, Erica

AU - Coriat, Caroline

AU - Wiedemann, Peter

AU - Ágoas, Victor

AU - Querques, Giuseppe

AU - Holz, Frank G.

AU - Nunes, Sandrina

AU - Alves, Dalila

AU - Neves, Catarina

AU - Santos, Torcato

AU - Ribeiro, Luisa

AU - Bandello, Francesco

AU - Tejerina, Amparo Navea

AU - Cunha-Vaz, José

PY - 2016

Y1 - 2016

N2 - To characterize the relevance of macular thickness changes in the inner and outer rings in the progression of macular edema in eyes/patients with diabetes type 2. A total of 374 type 2 diabetic patients with mild nonproliferative diabetic retinopathy (ETDRS levels 20-35) were included in a 12-month prospective observational study to identify retinopathy progression. Retinal thickness analyses were performed in 194 eyes/patients using Cirrus SD- OCT and 166 eyes/patients using Spectralis SD-OCT. The DRCR.net classification of subclinical and clinical macular edema was used. A composite grading of macular edema is proposed in this study. A total of 317 eyes/patients completed the study. SD-OCT identified clinical macular edema in 24 eyes/patients (6.7%) and subclinical macular edema in 104 eyes/patients (28.9%) at baseline. Increased thickness of the central subfield is the best predictor for the development of clinical macular edema, with 85.7% sensitivity and 71.9% specificity (OR: 2.57, 95% CI: 0.82-7.99). However, the involvement of the inner and outer rings is a cumulative predictor of progression to clinical macular edema (OR: 8.69, 95% CI: 2.85-26.52). A composite OCT grading of macular edema taking into account the retinal thickness changes in the inner and outer macular rings offers a simple way to characterize macular edema, with added clinical value

AB - To characterize the relevance of macular thickness changes in the inner and outer rings in the progression of macular edema in eyes/patients with diabetes type 2. A total of 374 type 2 diabetic patients with mild nonproliferative diabetic retinopathy (ETDRS levels 20-35) were included in a 12-month prospective observational study to identify retinopathy progression. Retinal thickness analyses were performed in 194 eyes/patients using Cirrus SD- OCT and 166 eyes/patients using Spectralis SD-OCT. The DRCR.net classification of subclinical and clinical macular edema was used. A composite grading of macular edema is proposed in this study. A total of 317 eyes/patients completed the study. SD-OCT identified clinical macular edema in 24 eyes/patients (6.7%) and subclinical macular edema in 104 eyes/patients (28.9%) at baseline. Increased thickness of the central subfield is the best predictor for the development of clinical macular edema, with 85.7% sensitivity and 71.9% specificity (OR: 2.57, 95% CI: 0.82-7.99). However, the involvement of the inner and outer rings is a cumulative predictor of progression to clinical macular edema (OR: 8.69, 95% CI: 2.85-26.52). A composite OCT grading of macular edema taking into account the retinal thickness changes in the inner and outer macular rings offers a simple way to characterize macular edema, with added clinical value

U2 - https://doi.org/10.1159/000441110

DO - https://doi.org/10.1159/000441110

M3 - Article

C2 - 26555067

SN - 0030-3747

VL - 55

SP - 19

EP - 25

JO - Ophthalmic research

JF - Ophthalmic research

IS - 1

ER -