TY - JOUR
T1 - Renal hyperfiltration defined by high estimated glomerular filtration rate: A risk factor for cardiovascular disease and mortality
AU - Kanbay, Mehmet
AU - Ertuglu, Lale A.
AU - Afsar, Baris
AU - Ozdogan, Elif
AU - Kucuksumer, Zeynep S.
AU - Ortiz, Alberto
AU - Covic, Adrian
AU - Kuwabara, Masanari
AU - Cherney, David Z. I.
AU - van Raalte, Daniel H.
AU - de Zeeuw, Dick
PY - 2019
Y1 - 2019
N2 - Renal hyperfiltration, defined as an increased glomerular filtration rate above normal values, is associated with early phases of kidney disease in the setting of various conditions such as obesity and diabetes. Although it is recognized that glomerular hyperfiltration, that is, increased filtration per nephron unit (usually studied at low glomerular filtration levels and often referred to as single nephron hyperfiltration), is a risk factor for the progression of chronic kidney disease, the implications of having renal hyperfiltration for cardiovascular disease and mortality risk are incompletely understood. Recent evidence from diverse populations, including healthy individuals and patients with diabetes or established cardiovascular disease, suggests that renal hyperfiltration is associated with a higher risk of cardiovascular disease and all-cause mortality. In this review, we critically summarize the existing studies, discuss possible mechanisms, and describe the remaining gaps in our knowledge regarding the association of renal hyperfiltration with cardiovascular disease and mortality risk.
AB - Renal hyperfiltration, defined as an increased glomerular filtration rate above normal values, is associated with early phases of kidney disease in the setting of various conditions such as obesity and diabetes. Although it is recognized that glomerular hyperfiltration, that is, increased filtration per nephron unit (usually studied at low glomerular filtration levels and often referred to as single nephron hyperfiltration), is a risk factor for the progression of chronic kidney disease, the implications of having renal hyperfiltration for cardiovascular disease and mortality risk are incompletely understood. Recent evidence from diverse populations, including healthy individuals and patients with diabetes or established cardiovascular disease, suggests that renal hyperfiltration is associated with a higher risk of cardiovascular disease and all-cause mortality. In this review, we critically summarize the existing studies, discuss possible mechanisms, and describe the remaining gaps in our knowledge regarding the association of renal hyperfiltration with cardiovascular disease and mortality risk.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85073486108&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/31297976
U2 - https://doi.org/10.1111/dom.13831
DO - https://doi.org/10.1111/dom.13831
M3 - Review article
C2 - 31297976
SN - 1462-8902
VL - 21
SP - 2368
EP - 2383
JO - Diabetes, obesity & metabolism
JF - Diabetes, obesity & metabolism
IS - 11
ER -