TY - JOUR
T1 - Repeated vaccination with tetanus toxoid of plasma donors with pre-existing specific IgE transiently elevates tetanus-specific IgE but does not induce allergic symptoms
AU - Unger, Peter-Paul A.
AU - Makuch, Mateusz
AU - Aalbers, Marja
AU - Derksen, Ninotska I. L.
AU - ten Brinke, Anja
AU - Aalberse, Rob C.
AU - Rispens, Theo
AU - van Ham, S. Marieke
PY - 2018/4
Y1 - 2018/4
N2 - IgE responses against allergens have acquired much attention due to their pathogenic nature as mediators of allergic reactions. In contrast, IgE responses against vaccines like Diphtheria-Tetanus-Pertussis (DTP) and the potential persistence of IgE production have received relatively little attention, presumably because of the low prevalence of allergic symptoms. In general, common early sensitivity reactions against vaccines, including tetanus toxoid, consist of mild local reactions and are not contraindicative of future vaccinations (1, 2). This article is protected by copyright. All rights reserved
AB - IgE responses against allergens have acquired much attention due to their pathogenic nature as mediators of allergic reactions. In contrast, IgE responses against vaccines like Diphtheria-Tetanus-Pertussis (DTP) and the potential persistence of IgE production have received relatively little attention, presumably because of the low prevalence of allergic symptoms. In general, common early sensitivity reactions against vaccines, including tetanus toxoid, consist of mild local reactions and are not contraindicative of future vaccinations (1, 2). This article is protected by copyright. All rights reserved
KW - Humans
KW - Immunization, Secondary
KW - Immunoglobulin E/blood
KW - Immunoglobulin G/blood
KW - Tetanus Toxoid/immunology
KW - Vaccination
U2 - https://doi.org/10.1111/cea.13107
DO - https://doi.org/10.1111/cea.13107
M3 - Article
C2 - 29383792
SN - 0954-7894
VL - 48
SP - 479
EP - 482
JO - Clinical and experimental allergy
JF - Clinical and experimental allergy
IS - 4
ER -