Resource allocation in utero and health in later life

D. J.P. Barker, M. Lampl, T. Roseboom, N. Winder

Research output: Contribution to journalArticleAcademicpeer-review

60 Citations (Scopus)

Abstract

The way that a fetus obtains and allocates nutritional resources has profound consequences for its life-long health. Under the new developmental model for the origins of chronic disease, the causes to be identified are linked to normal variations in the processes of feto-placental development, that are associated with differences in the supply of nutrients to the baby. These differences programme the function of a few key systems that are linked to chronic disease, including the immune system, anti-oxidant defences, inflammation, and the number and quality of stem cells. There is not a separate cause for each different disease. Which chronic disease originates during development may depend more on timing than on qualitative differences in experience.

Original languageEnglish
Pages (from-to)e30-e34
JournalPlacenta
Volume33
Issue numberSUPPL. 2
DOIs
Publication statusPublished - Nov 2012

Keywords

  • Fetal programming
  • Maternal nutrition
  • Placenta
  • Sex differences

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