TY - JOUR
T1 - Response and Side Effects Using Stimulant Medication in Older Adults With ADHD: An Observational Archive Study
AU - Michielsen, Marieke
AU - Kleef, Didi
AU - Bijlenga, Denise
AU - Zwennes, Cinderella
AU - Dijkhuizen, Kim
AU - Smulders, Jan
AU - Hazewinkel, Andreia
AU - Beekman, Aartjan T. F.
AU - Kooij, J. J. Sandra
N1 - Publisher Copyright: © The Author(s) 2020. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/6/11
Y1 - 2020/6/11
N2 - Objective: To examine the naturalistic response to and cardiovascular side effects of stimulant medication in older adults with ADHD. Methods: Electronic Health Record (EHR) data of adult patients with ADHD (≥55 years) at the specialized PsyQ outpatient clinic for adult ADHD (n = 113, 55-79 years) were collected. Response, cardiovascular status, side effects, and provided medical care before and after the first ADHD medication dose have been recorded. Results: A total of 65% of the patients reported positive response to the medication, and 42% of the patients quit their medication due to side effects or nonresponse. There was a small but significant decrease in weight and increase in heart rate before and after methylphenidate use. Conclusion: Our results indicate that the use of stimulants may be a relatively safe and effective treatment for older adults with ADHD, under the condition that the cardiovascular parameters are monitored before and during pharmacological treatment. Randomized controlled trials (RCTs) are needed to confirm these findings.
AB - Objective: To examine the naturalistic response to and cardiovascular side effects of stimulant medication in older adults with ADHD. Methods: Electronic Health Record (EHR) data of adult patients with ADHD (≥55 years) at the specialized PsyQ outpatient clinic for adult ADHD (n = 113, 55-79 years) were collected. Response, cardiovascular status, side effects, and provided medical care before and after the first ADHD medication dose have been recorded. Results: A total of 65% of the patients reported positive response to the medication, and 42% of the patients quit their medication due to side effects or nonresponse. There was a small but significant decrease in weight and increase in heart rate before and after methylphenidate use. Conclusion: Our results indicate that the use of stimulants may be a relatively safe and effective treatment for older adults with ADHD, under the condition that the cardiovascular parameters are monitored before and during pharmacological treatment. Randomized controlled trials (RCTs) are needed to confirm these findings.
KW - attention-deficit/hyperactivity disorder
KW - geriatric
KW - stimulants
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85086101139&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/32508213
UR - http://www.scopus.com/inward/record.url?scp=85086101139&partnerID=8YFLogxK
U2 - https://doi.org/10.1177/1087054720925884
DO - https://doi.org/10.1177/1087054720925884
M3 - Article
C2 - 32508213
SN - 1087-0547
VL - 1.8 2020
SP - 1
EP - 8
JO - Journal of Attention Disorders
JF - Journal of Attention Disorders
M1 - 1087054720925884
ER -