TY - JOUR
T1 - Resting-state functional connectivity in adults with childhood emotional maltreatment
AU - Van Der Werff, S. J.A.
AU - Pannekoek, J. N.
AU - Veer, I. M.
AU - Van Tol, M. J.
AU - Aleman, A.
AU - Veltman, D. J.
AU - Zitman, F. G.
AU - Rombouts, S. A.R.B.
AU - Elzinga, B. M.
AU - Van Der Wee, N. J.A.
PY - 2013/9
Y1 - 2013/9
N2 - Background Childhood emotional maltreatment (CEM) has been associated with disturbances in emotional and behavioral functioning, and with changes in regional brain morphology. However, whether CEM has any effect on the intrinsic organization of the brain is not known. In this study, we investigated the effects of CEM on resting-state functional connectivity (RSFC) using seeds in the limbic network, the default-mode network (DMN) and the salience network, and the left dorsomedial prefrontal cortex (dmPFC). Method Using 3-T magnetic resonance imaging (MRI), resting-state functional MRI (RS-fMRI) scans were obtained. We defined seeds in the bilateral amygdala, the dorsal anterior cingulate cortex (dACC), the posterior cingulate cortex (PCC) and the left dmPFC, and used these to examine whether individuals reporting CEM (n=44) differed from individuals reporting no CEM (n=44) in RSFC with other brain regions. The two groups were matched for age, gender, handedness and the presence of psychopathology. Results CEM was associated with decreased RSFC between the right amygdala and the bilateral precuneus and a cluster extending from the left insula to the hippocampus and putamen. In addition, CEM was associated with decreased RSFC between the dACC and the precuneus and also frontal regions of the brain. Conclusions We found that CEM has a profound effect on RSFC in the limbic network and the salience network. Regions that show aberrant connectivity are related to episodic memory encoding, retrieval and self-processing operations.
AB - Background Childhood emotional maltreatment (CEM) has been associated with disturbances in emotional and behavioral functioning, and with changes in regional brain morphology. However, whether CEM has any effect on the intrinsic organization of the brain is not known. In this study, we investigated the effects of CEM on resting-state functional connectivity (RSFC) using seeds in the limbic network, the default-mode network (DMN) and the salience network, and the left dorsomedial prefrontal cortex (dmPFC). Method Using 3-T magnetic resonance imaging (MRI), resting-state functional MRI (RS-fMRI) scans were obtained. We defined seeds in the bilateral amygdala, the dorsal anterior cingulate cortex (dACC), the posterior cingulate cortex (PCC) and the left dmPFC, and used these to examine whether individuals reporting CEM (n=44) differed from individuals reporting no CEM (n=44) in RSFC with other brain regions. The two groups were matched for age, gender, handedness and the presence of psychopathology. Results CEM was associated with decreased RSFC between the right amygdala and the bilateral precuneus and a cluster extending from the left insula to the hippocampus and putamen. In addition, CEM was associated with decreased RSFC between the dACC and the precuneus and also frontal regions of the brain. Conclusions We found that CEM has a profound effect on RSFC in the limbic network and the salience network. Regions that show aberrant connectivity are related to episodic memory encoding, retrieval and self-processing operations.
KW - Amygdala
KW - childhood emotional maltreatment
KW - default mode network
KW - precuneus
KW - resting-state functional connectivity
KW - salience network
UR - http://www.scopus.com/inward/record.url?scp=84881441389&partnerID=8YFLogxK
U2 - https://doi.org/10.1017/S0033291712002942
DO - https://doi.org/10.1017/S0033291712002942
M3 - Article
C2 - 23254143
SN - 0033-2917
VL - 43
SP - 1825
EP - 1836
JO - Psychological Medicine
JF - Psychological Medicine
IS - 9
ER -