TY - JOUR
T1 - Retrospective Review of Blood Culture-Confirmed Cases of Enteric Fever in Navi Mumbai, India
T2 - 2014-2018
AU - Jayaprasad, Niniya
AU - Borhade, Priyanka
AU - LeBoa, Christopher
AU - Date, Kashmira
AU - Joshi, Shrikrishna
AU - Shimpi, Rahul
AU - Andrews, Jason R.
AU - Luby, Stephen P.
AU - Hoffman, Seth A.
N1 - Funding Information: Financial support: This work was supported by Bill and Melinda Gates Foundation grant OPP1169264 (principal investigator: S. P. L.). S. A. H. is supported in part by the NIH under National Institute of Allergy and Infectious Diseases grant T32AI007502, as well as by the Stanford Maternal and Child Health Research Institute. K. D. reports a salary from the Centers for Disease Control and Prevention. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position, policies, or views of the Centers for Disease Control and Prevention or the World Health Organization. Publisher Copyright: Copyright © 2023 The author(s)
PY - 2023/9/6
Y1 - 2023/9/6
N2 - India has one of the highest estimated burdens of enteric fever globally. Prior to the implementation of Typbar-TCV typhoid conjugate vaccine (TCV) in a public sector pediatric immunization campaign in Navi Mumbai, India, we conducted a retrospective review of blood culture-confirmed cases of typhoid and paratyphoid fevers to estimate the local burden of disease. This review included all blood cultures processed at a central microbiology laboratory, serving multiple hospitals, in Navi Mumbai (January 2014-May 2018) that tested positive for either Salmonella Typhi or Salmonella Paratyphi A. Of 40,670 blood cultures analyzed, 1,309 (3.2%) were positive for S. Typhi (1,201 [92%]) or S. Paratyphi A (108 [8%]). Culture positivity was highest in the last months of the dry season (April-June). Our findings indicate a substantial burden of enteric fever in Navi Mumbai and support the importance of TCV immunization campaigns and improved water, sanitation, and hygiene.
AB - India has one of the highest estimated burdens of enteric fever globally. Prior to the implementation of Typbar-TCV typhoid conjugate vaccine (TCV) in a public sector pediatric immunization campaign in Navi Mumbai, India, we conducted a retrospective review of blood culture-confirmed cases of typhoid and paratyphoid fevers to estimate the local burden of disease. This review included all blood cultures processed at a central microbiology laboratory, serving multiple hospitals, in Navi Mumbai (January 2014-May 2018) that tested positive for either Salmonella Typhi or Salmonella Paratyphi A. Of 40,670 blood cultures analyzed, 1,309 (3.2%) were positive for S. Typhi (1,201 [92%]) or S. Paratyphi A (108 [8%]). Culture positivity was highest in the last months of the dry season (April-June). Our findings indicate a substantial burden of enteric fever in Navi Mumbai and support the importance of TCV immunization campaigns and improved water, sanitation, and hygiene.
UR - http://www.scopus.com/inward/record.url?scp=85170110424&partnerID=8YFLogxK
U2 - https://doi.org/10.4269/ajtmh.23-0102
DO - https://doi.org/10.4269/ajtmh.23-0102
M3 - Article
C2 - 37549903
SN - 0002-9637
VL - 109
SP - 571
EP - 574
JO - The American journal of tropical medicine and hygiene
JF - The American journal of tropical medicine and hygiene
IS - 3
ER -