TY - JOUR
T1 - Returning of antiretroviral medication dispensed over a period of 8 months suggests non-adherence despite full adherence according to real time medication monitoring
AU - Ngowi, Kennedy Michael
AU - Masika, Lydia
AU - Lyamuya, Furaha
AU - Muro, Eva
AU - Mmbaga, Blandina T.
AU - Sprangers, Mirjam A. G.
AU - Nieuwkerk, Pythia T.
AU - Aarnoutse, Rob E.
AU - Reiss, Peter
AU - Sumari-de Boer, I. Marion
PY - 2020/9/10
Y1 - 2020/9/10
N2 - Real-time medication monitoring (RTMM) may potentially enhance adherence to antiretroviral treatment (ART). We describe a participant in an ongoing trial who, shortly after completing trial participation, died of cryptococcal meningitis despite high levels of adherence according to self-report, pill-counts and RTMM (> 99%). However, she evidenced consistently high HIV viral load throughout the 48-week study follow-up. Subsequently, her relatives unsolicitedly returned eight months' dispensed ART medication that she was supposed to have taken. This brief report illustrates the challenges of adherence measurements including RTMM, and reinforces the need to combine adherence assessments with viral load monitoring in HIV care.
AB - Real-time medication monitoring (RTMM) may potentially enhance adherence to antiretroviral treatment (ART). We describe a participant in an ongoing trial who, shortly after completing trial participation, died of cryptococcal meningitis despite high levels of adherence according to self-report, pill-counts and RTMM (> 99%). However, she evidenced consistently high HIV viral load throughout the 48-week study follow-up. Subsequently, her relatives unsolicitedly returned eight months' dispensed ART medication that she was supposed to have taken. This brief report illustrates the challenges of adherence measurements including RTMM, and reinforces the need to combine adherence assessments with viral load monitoring in HIV care.
KW - ART
KW - Adherence
KW - Case report
KW - Realtime medication monitoring
KW - mHealth
UR - http://www.scopus.com/inward/record.url?scp=85090817635&partnerID=8YFLogxK
U2 - https://doi.org/10.1186/s12981-020-00313-z
DO - https://doi.org/10.1186/s12981-020-00313-z
M3 - Article
C2 - 32912282
SN - 1742-6405
VL - 17
SP - 57
JO - AIDS research and therapy
JF - AIDS research and therapy
IS - 1
M1 - 57
ER -