TY - JOUR
T1 - Review article: Regulation of glucose production with special attention to nonclassical regulatory mechanisms: a review
AU - Corssmit, E. P.
AU - Romijn, J. A.
AU - Sauerwein, H. P.
PY - 2001
Y1 - 2001
N2 - Hepatic glycogenolysis and gluconeogenesis are essential processes for the prevention of hypoglycemia during short-term starvation. As has been calculated from stable isotope studies, gluconeogenesis accounts for approximately 35% to 50% of total basal glucose production, glycogenolysis for the other 50% to 65%. In long-term starvation, the kidney also contributes to glucose production by gluconeogenesis. Glucose production is regulated by the interaction of different regulatory mechanisms, eg, by glucoregulatory hormones, glucose itself, and gluconeogenic substrates. In the last decades, more insight has been gained into the importance of the autonomous nervous system and the existence of an extensive paracrine network in the liver that seems to exert a potent glucoregulatory role as well. This review is focused on the regulation of hepatic glucose production by the autonomous nervous system and the paracrine network, with special emphasis on studies carried out in human subjects
AB - Hepatic glycogenolysis and gluconeogenesis are essential processes for the prevention of hypoglycemia during short-term starvation. As has been calculated from stable isotope studies, gluconeogenesis accounts for approximately 35% to 50% of total basal glucose production, glycogenolysis for the other 50% to 65%. In long-term starvation, the kidney also contributes to glucose production by gluconeogenesis. Glucose production is regulated by the interaction of different regulatory mechanisms, eg, by glucoregulatory hormones, glucose itself, and gluconeogenic substrates. In the last decades, more insight has been gained into the importance of the autonomous nervous system and the existence of an extensive paracrine network in the liver that seems to exert a potent glucoregulatory role as well. This review is focused on the regulation of hepatic glucose production by the autonomous nervous system and the paracrine network, with special emphasis on studies carried out in human subjects
U2 - https://doi.org/10.1053/meta.2001.24195
DO - https://doi.org/10.1053/meta.2001.24195
M3 - Review article
C2 - 11436176
SN - 0026-0495
VL - 50
SP - 742
EP - 755
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
IS - 7
ER -