Ribonuclease H1 maps to chromosome 2 and has at least three pseudogene loci in the human genome

Anneloor L. M. A. ten Asbroek; Marjon van Groenigen; Marja E. Jakobs; Cindy Koevoets; Bert Janssen; Frank Baas

doi:https://doi.org/10.1006/geno.2002.6776

Ribonuclease H1 maps to chromosome 2 and has at least three pseudogene loci in the human genome

Anneloor L. M. A. ten Asbroek, Marjon van Groenigen, Marja E. Jakobs, Cindy Koevoets, Bert Janssen, Frank Baas

Genome Analysis (AMC)

Research output: Contribution to journal › Article › Academic › peer-review

4 Citations (Scopus)

Abstract

We have analyzed the genomic structure of ribonuclease H1 (RNase H1) loci in the human genome. Human PAC library screening combined with database searches indicated that several loci are present. The transcribed gene is localized on chromosome 2p25. This was confirmed by RNA analysis of a monochromosomal hybrid cell line that expressed human chromosome 2. These data contradict a previous report, as well as the current Human Genome Project (HGP) annotation, which had placed the gene on chromosome 17p11.2. This location represents a pseudogene. Another highly similar pseudogene is present at a separate locus located more distal on chromosome 17p, while a third pseudogene is localized on chromosome 1q

Original language	English
Pages (from-to)	818-823
Journal	Genomics
Volume	79
Issue number	6
DOIs	https://doi.org/10.1006/geno.2002.6776
Publication status	Published - 2002

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https://doi.org/10.1006/geno.2002.6776

Cite this

@article{915d3616b6374d39adb5c5fb83179f26,

title = "Ribonuclease H1 maps to chromosome 2 and has at least three pseudogene loci in the human genome",

abstract = "We have analyzed the genomic structure of ribonuclease H1 (RNase H1) loci in the human genome. Human PAC library screening combined with database searches indicated that several loci are present. The transcribed gene is localized on chromosome 2p25. This was confirmed by RNA analysis of a monochromosomal hybrid cell line that expressed human chromosome 2. These data contradict a previous report, as well as the current Human Genome Project (HGP) annotation, which had placed the gene on chromosome 17p11.2. This location represents a pseudogene. Another highly similar pseudogene is present at a separate locus located more distal on chromosome 17p, while a third pseudogene is localized on chromosome 1q",

author = "{ten Asbroek}, {Anneloor L. M. A.} and {van Groenigen}, Marjon and Jakobs, {Marja E.} and Cindy Koevoets and Bert Janssen and Frank Baas",

year = "2002",

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journal = "Genomics",

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T1 - Ribonuclease H1 maps to chromosome 2 and has at least three pseudogene loci in the human genome

AU - ten Asbroek, Anneloor L. M. A.

AU - van Groenigen, Marjon

AU - Jakobs, Marja E.

AU - Koevoets, Cindy

AU - Janssen, Bert

AU - Baas, Frank

PY - 2002

Y1 - 2002

N2 - We have analyzed the genomic structure of ribonuclease H1 (RNase H1) loci in the human genome. Human PAC library screening combined with database searches indicated that several loci are present. The transcribed gene is localized on chromosome 2p25. This was confirmed by RNA analysis of a monochromosomal hybrid cell line that expressed human chromosome 2. These data contradict a previous report, as well as the current Human Genome Project (HGP) annotation, which had placed the gene on chromosome 17p11.2. This location represents a pseudogene. Another highly similar pseudogene is present at a separate locus located more distal on chromosome 17p, while a third pseudogene is localized on chromosome 1q

AB - We have analyzed the genomic structure of ribonuclease H1 (RNase H1) loci in the human genome. Human PAC library screening combined with database searches indicated that several loci are present. The transcribed gene is localized on chromosome 2p25. This was confirmed by RNA analysis of a monochromosomal hybrid cell line that expressed human chromosome 2. These data contradict a previous report, as well as the current Human Genome Project (HGP) annotation, which had placed the gene on chromosome 17p11.2. This location represents a pseudogene. Another highly similar pseudogene is present at a separate locus located more distal on chromosome 17p, while a third pseudogene is localized on chromosome 1q

U2 - https://doi.org/10.1006/geno.2002.6776

DO - https://doi.org/10.1006/geno.2002.6776

M3 - Article

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SN - 0888-7543

VL - 79

SP - 818

EP - 823

JO - Genomics

JF - Genomics

IS - 6

ER -