TY - JOUR
T1 - Rich-club neurocircuitry
T2 - Function, evolution, and vulnerability
AU - Griffa, Alessandra
AU - Van Den Heuvel, Martijn P.
PY - 2018/6/1
Y1 - 2018/6/1
N2 - Over the past decades, network neuroscience has played a fundamental role in the understanding of large-scale brain connectivity architecture. Brains, and more generally nervous systems, can be modeled as sets of elements (neurons, assemblies, or cortical chunks) that dynamically interact through a highly structured and adaptive neurocircuitry. An interesting property of neural networks is that elements rich in connections are central to the network organization and tend to interconnect strongly with each other, forming so-called rich clubs. The ubiquity of rich-club organization across different species and scales of investigation suggests that this topology could be a distinctive feature of biological systems with information processing capabilities. This review surveys recent neuroimaging, computational, and cross-species comparative literature to offer an insight into the function and origin of rich-club architecture in nervous systems, discussing its relevance to human cognition and behavior, and vulnerability to brain disorders.
AB - Over the past decades, network neuroscience has played a fundamental role in the understanding of large-scale brain connectivity architecture. Brains, and more generally nervous systems, can be modeled as sets of elements (neurons, assemblies, or cortical chunks) that dynamically interact through a highly structured and adaptive neurocircuitry. An interesting property of neural networks is that elements rich in connections are central to the network organization and tend to interconnect strongly with each other, forming so-called rich clubs. The ubiquity of rich-club organization across different species and scales of investigation suggests that this topology could be a distinctive feature of biological systems with information processing capabilities. This review surveys recent neuroimaging, computational, and cross-species comparative literature to offer an insight into the function and origin of rich-club architecture in nervous systems, discussing its relevance to human cognition and behavior, and vulnerability to brain disorders.
KW - Anatomical connectivity
KW - Clinical neuroscience
KW - Comparative connectomics
KW - Complexity
KW - Connectome
KW - Evolution
KW - Functional dynamics
KW - Functional integration
KW - Graph analysis
KW - Neural network
KW - Neuroimaging
KW - Rich club
UR - http://www.scopus.com/inward/record.url?scp=85055058611&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85055058611&partnerID=8YFLogxK
UR - https://www.dialogues-cns.org/contents-20-2/
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85055058611&origin=inward
M3 - Review article
SN - 1294-8322
VL - 20
SP - 121
EP - 132
JO - Dialogues in Clinical Neuroscience
JF - Dialogues in Clinical Neuroscience
IS - 2
ER -