Right-ventricular failure is associated with increased mitochondrial complex II activity and production of reactive oxygen species.

E.M. Redout, M.J. Wagner, M.J. Zuidwijk, C. Boer, R.J.P. Musters, C. van Hardeveld, W.J.S. Paulus, W.S. Simonides

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Objective: Reactive oxygen species (ROS) have been implicated in the progression of ventricular hypertrophy to congestive heart failure. However, the source of increased oxidative stress in cardiomyocytes remains unclear. Methods: Here we examined NADPH oxidase and mitochondria as sources of ventricular ROS production in a rat model of right-ventricular (RV) failure (CHF) induced by pulmonary arterial hypertension (PAH). Results: Western analysis showed increased expression of the catalytic subunit gp91
Original languageEnglish
Pages (from-to)770-781
Number of pages12
JournalCardiovascular research
Issue number4
Publication statusPublished - 1 Sept 2007


  • Heart failure
  • Mitochondria
  • NADPH oxidase
  • Reactive oxygen species

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