Right-ventricular failure is associated with increased mitochondrial complex II activity and production of reactive oxygen species.

E.M. Redout; M.J. Wagner; M.J. Zuidwijk; C. Boer; R.J.P. Musters; C. van Hardeveld; W.J.S. Paulus; W.S. Simonides

doi:https://doi.org/10.1016/j.cardiores.2007.05.012

Right-ventricular failure is associated with increased mitochondrial complex II activity and production of reactive oxygen species.

E.M. Redout, M.J. Wagner, M.J. Zuidwijk, C. Boer, R.J.P. Musters, C. van Hardeveld, W.J.S. Paulus, W.S. Simonides

Research output: Contribution to journal › Article › Academic › peer-review

143 Citations (Scopus)

Abstract

Objective: Reactive oxygen species (ROS) have been implicated in the progression of ventricular hypertrophy to congestive heart failure. However, the source of increased oxidative stress in cardiomyocytes remains unclear. Methods: Here we examined NADPH oxidase and mitochondria as sources of ventricular ROS production in a rat model of right-ventricular (RV) failure (CHF) induced by pulmonary arterial hypertension (PAH). Results: Western analysis showed increased expression of the catalytic subunit gp91

Original language	English
Pages (from-to)	770-781
Number of pages	12
Journal	Cardiovascular research
Volume	74
Issue number	4
DOIs	https://doi.org/10.1016/j.cardiores.2007.05.012
Publication status	Published - 1 Sept 2007

Keywords

Heart failure
Mitochondria
NADPH oxidase
Reactive oxygen species

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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https://doi.org/10.1016/j.cardiores.2007.05.012

Cite this

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title = "Right-ventricular failure is associated with increased mitochondrial complex II activity and production of reactive oxygen species.",

abstract = "Objective: Reactive oxygen species (ROS) have been implicated in the progression of ventricular hypertrophy to congestive heart failure. However, the source of increased oxidative stress in cardiomyocytes remains unclear. Methods: Here we examined NADPH oxidase and mitochondria as sources of ventricular ROS production in a rat model of right-ventricular (RV) failure (CHF) induced by pulmonary arterial hypertension (PAH). Results: Western analysis showed increased expression of the catalytic subunit gp91",

keywords = "Heart failure, Mitochondria, NADPH oxidase, Reactive oxygen species",

author = "E.M. Redout and M.J. Wagner and M.J. Zuidwijk and C. Boer and R.J.P. Musters and {van Hardeveld}, C. and W.J.S. Paulus and W.S. Simonides",

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T1 - Right-ventricular failure is associated with increased mitochondrial complex II activity and production of reactive oxygen species.

AU - Redout, E.M.

AU - Wagner, M.J.

AU - Zuidwijk, M.J.

AU - Boer, C.

AU - Musters, R.J.P.

AU - van Hardeveld, C.

AU - Paulus, W.J.S.

AU - Simonides, W.S.

PY - 2007/9/1

Y1 - 2007/9/1

N2 - Objective: Reactive oxygen species (ROS) have been implicated in the progression of ventricular hypertrophy to congestive heart failure. However, the source of increased oxidative stress in cardiomyocytes remains unclear. Methods: Here we examined NADPH oxidase and mitochondria as sources of ventricular ROS production in a rat model of right-ventricular (RV) failure (CHF) induced by pulmonary arterial hypertension (PAH). Results: Western analysis showed increased expression of the catalytic subunit gp91

AB - Objective: Reactive oxygen species (ROS) have been implicated in the progression of ventricular hypertrophy to congestive heart failure. However, the source of increased oxidative stress in cardiomyocytes remains unclear. Methods: Here we examined NADPH oxidase and mitochondria as sources of ventricular ROS production in a rat model of right-ventricular (RV) failure (CHF) induced by pulmonary arterial hypertension (PAH). Results: Western analysis showed increased expression of the catalytic subunit gp91

KW - Heart failure

KW - Mitochondria

KW - NADPH oxidase

KW - Reactive oxygen species

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U2 - https://doi.org/10.1016/j.cardiores.2007.05.012

DO - https://doi.org/10.1016/j.cardiores.2007.05.012

M3 - Article

C2 - 17582388

SN - 0008-6363

VL - 74

SP - 770

EP - 781

JO - Cardiovascular research

JF - Cardiovascular research

IS - 4

ER -

Right-ventricular failure is associated with increased mitochondrial complex II activity and production of reactive oxygen species.

Abstract

Keywords

UN SDGs

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