Ring chromosome 4 as the sole cytogenetic anomaly in a chondroblastoma: A case report and review of the literature

Shama L. Van Zelderen-Bhola, Judith V.M.G. Bovée, Hans W. Wessels, Paul Mollevanger, Jeroen V. Nijhuis, Jaap D.H. Van Eendenburg, Anthonie H.M. Taminiau, Pancras C.W. Hogendoorn

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Chromosome analysis of a chondroblastoma of the right distal femur in a 31-year-old male patient revealed o ring chromosome 4 in approximately one- third of the analyzed cells. The remaining cells had a normal karyotype. These findings were subsequently confirmed by fluorescence in situ hybridization (FISH) with a chromosome-4-specific library. FISH with cosmids pC847.351 (4p16.3) and cT171 (4q35) revealed that fewer than 300 kilobase pairs (kbp) are deleted. To our knowledge, ring chromosome 4 has never been reported in this type of neoplasm. There are, however, several reports of chondroblastoma with other chromosome abnormalities, but the relation of these anomalies to this tumor specifically is unclear. In this report, we also provide a review of the literature concerning cytogenetic studies in chondroblastoma. The possible significance of ring chromosome 4 in this type of tumor is discussed.

Original languageEnglish
Pages (from-to)109-112
Number of pages4
JournalCancer genetics and cytogenetics
Issue number2
Publication statusPublished - Sept 1998

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