TY - JOUR
T1 - Ring chromosome 4 as the sole cytogenetic anomaly in a chondroblastoma
T2 - A case report and review of the literature
AU - Van Zelderen-Bhola, Shama L.
AU - Bovée, Judith V.M.G.
AU - Wessels, Hans W.
AU - Mollevanger, Paul
AU - Nijhuis, Jeroen V.
AU - Van Eendenburg, Jaap D.H.
AU - Taminiau, Anthonie H.M.
AU - Hogendoorn, Pancras C.W.
PY - 1998/9
Y1 - 1998/9
N2 - Chromosome analysis of a chondroblastoma of the right distal femur in a 31-year-old male patient revealed o ring chromosome 4 in approximately one- third of the analyzed cells. The remaining cells had a normal karyotype. These findings were subsequently confirmed by fluorescence in situ hybridization (FISH) with a chromosome-4-specific library. FISH with cosmids pC847.351 (4p16.3) and cT171 (4q35) revealed that fewer than 300 kilobase pairs (kbp) are deleted. To our knowledge, ring chromosome 4 has never been reported in this type of neoplasm. There are, however, several reports of chondroblastoma with other chromosome abnormalities, but the relation of these anomalies to this tumor specifically is unclear. In this report, we also provide a review of the literature concerning cytogenetic studies in chondroblastoma. The possible significance of ring chromosome 4 in this type of tumor is discussed.
AB - Chromosome analysis of a chondroblastoma of the right distal femur in a 31-year-old male patient revealed o ring chromosome 4 in approximately one- third of the analyzed cells. The remaining cells had a normal karyotype. These findings were subsequently confirmed by fluorescence in situ hybridization (FISH) with a chromosome-4-specific library. FISH with cosmids pC847.351 (4p16.3) and cT171 (4q35) revealed that fewer than 300 kilobase pairs (kbp) are deleted. To our knowledge, ring chromosome 4 has never been reported in this type of neoplasm. There are, however, several reports of chondroblastoma with other chromosome abnormalities, but the relation of these anomalies to this tumor specifically is unclear. In this report, we also provide a review of the literature concerning cytogenetic studies in chondroblastoma. The possible significance of ring chromosome 4 in this type of tumor is discussed.
UR - http://www.scopus.com/inward/record.url?scp=0032171656&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/S0165-4608(98)00016-8
DO - https://doi.org/10.1016/S0165-4608(98)00016-8
M3 - Article
C2 - 9723025
SN - 0165-4608
VL - 105
SP - 109
EP - 112
JO - Cancer genetics and cytogenetics
JF - Cancer genetics and cytogenetics
IS - 2
ER -