Abstract
OBJECTIVE: To identify additional risk factors and the corresponding probability of carrying a chromosome abnormality in couples with two or more miscarriages.
DESIGN: Nested case-control study.
METHOD: In 6 centres for clinical genetics in the Netherlands, data were collected from couples referred for karyotyping after 2 2 miscarriages from 1992-2000. Factors influencing the probability of carrier status were examined. The corresponding probability of carrier status was calculated for the various combinations of these factors.
RESULTS: In total 279 carrier couples and 428 non-carrier couples were included. 4 independent factors influencing the probability of carrier status were identified: a younger maternal age at the time of second miscarriage, a history of > or = 3 miscarriages, a history of > 2 miscarriages in a brother or sister of either partner, and a history of> 2 miscarriages in parents of either partner. The calculated probability of carrier status in couples referred for chromosome analysis after two or more miscarriages, varied between 0.5-10.2%. In 18% of couples included, the risk was found to be so low (< 2.2%), that in couples with comparable risk factors, it may not be necessary to perform karyotyping.
CONCLUSION: This study demonstrated that the probability of carrier status in couples with > or = 2 miscarriages is modified by additional factors. Selective chromosome analysis would result in a more effective referral policy and therefore decrease the number of chromosome analyses and lower the costs.
Translated title of the contribution | Risk factors for structural chromosomal abnormality in > or = 2 miscarriages, as an instrument for selective karyotyping |
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Original language | Dutch |
Pages (from-to) | 863-7 |
Number of pages | 5 |
Journal | Nederlands Tijdschrift voor Geneeskunde |
Volume | 151 |
Issue number | 15 |
Publication status | Published - 14 Apr 2007 |
Keywords
- Abortion, Habitual/genetics
- Abortion, Spontaneous/genetics
- Adult
- Case-Control Studies
- Chromosome Aberrations
- Female
- Genetic Carrier Screening
- Genetic Predisposition to Disease
- Genetic Testing
- Heterozygote
- Humans
- Karyotyping
- Male
- Maternal Age
- Patient Selection
- Pregnancy
- Risk Assessment
- Risk Factors