TY - JOUR
T1 - Risk assessment in medically treated chronic thromboembolic pulmonary hypertension patients
AU - Delcroix, Marion
AU - Staehler, Gerd
AU - Gall, Henning
AU - Grünig, Ekkehard
AU - Held, Matthias
AU - Halank, Michael
AU - Klose, Hans
AU - Vonk-Noordegraaf, Anton
AU - Rosenkranz, Stephan
AU - Pepke-Zaba, Joanna
AU - Opitz, Christian F.
AU - Gibbs, J. Simon R.
AU - Lange, Tobias J.
AU - Tsangaris, Iraklis
AU - Huscher, Doerte
AU - Pittrow, David
AU - Olsson, Karen M.
AU - Hoeper, Marius M.
PY - 2018
Y1 - 2018
N2 - Abbreviated versions of the risk stratification strategy of the European Society of Cardiology (ESC)/European Respiratory Society (ERS) pulmonary hypertension guidelines have been recently validated in patients with pulmonary arterial hypertension. We aimed to investigate their prognostic value in medically treated chronic thromboembolic pulmonary hypertension (CTEPH) patients from the COMPERA registry, which collects six variables of interest (World Health Organization Functional Class, 6-min walk distance, brain natriuretic peptide, right atrial pressure, cardiac index and mixed venous oxygen saturation).We included patients with at least one follow-up visit, no pulmonary endarterectomy and at least three of the six variables available, and classified the patients into low-, intermediate- and high-risk groups. As a secondary analysis, the number of noninvasive low-risk criteria was counted. The association between risk assessment and survival was evaluated.Data from inclusion and follow-up (median 7 months) visits were available for 561 and 231 patients, respectively. Baseline 1- and 5-year survival estimates were significantly different (p<0.0001) in the baseline low-risk (98.6% and 88.3%, respectively), intermediate-risk (94.9% and 61.8%, respectively) and high-risk (75.5% and 32.9%, respectively) cohorts. Follow-up data were even more discriminative, with 100%, 92% and 69% 1-year survival, respectively. The number of low-risk noninvasive criteria was also associated with survival.These analyses suggest that the ESC/ERS risk assessment may be applicable in patients with medically treated CTEPH.
AB - Abbreviated versions of the risk stratification strategy of the European Society of Cardiology (ESC)/European Respiratory Society (ERS) pulmonary hypertension guidelines have been recently validated in patients with pulmonary arterial hypertension. We aimed to investigate their prognostic value in medically treated chronic thromboembolic pulmonary hypertension (CTEPH) patients from the COMPERA registry, which collects six variables of interest (World Health Organization Functional Class, 6-min walk distance, brain natriuretic peptide, right atrial pressure, cardiac index and mixed venous oxygen saturation).We included patients with at least one follow-up visit, no pulmonary endarterectomy and at least three of the six variables available, and classified the patients into low-, intermediate- and high-risk groups. As a secondary analysis, the number of noninvasive low-risk criteria was counted. The association between risk assessment and survival was evaluated.Data from inclusion and follow-up (median 7 months) visits were available for 561 and 231 patients, respectively. Baseline 1- and 5-year survival estimates were significantly different (p<0.0001) in the baseline low-risk (98.6% and 88.3%, respectively), intermediate-risk (94.9% and 61.8%, respectively) and high-risk (75.5% and 32.9%, respectively) cohorts. Follow-up data were even more discriminative, with 100%, 92% and 69% 1-year survival, respectively. The number of low-risk noninvasive criteria was also associated with survival.These analyses suggest that the ESC/ERS risk assessment may be applicable in patients with medically treated CTEPH.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85056381788&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30337446
U2 - https://doi.org/10.1183/13993003.00248-2018
DO - https://doi.org/10.1183/13993003.00248-2018
M3 - Article
C2 - 30337446
SN - 0903-1936
VL - 52
JO - European respiratory journal
JF - European respiratory journal
IS - 5
ER -