TY - JOUR
T1 - Risk Factors for Death from Invasive Pneumococcal Disease, Europe, 2010
AU - Navarro-Torné, Adoración
AU - Dias, Joana Gomes
AU - Hruba, Frantiska
AU - Lopalco, Pier Luigi
AU - Pastore-Celentano, Lucia
AU - Gauci, Andrew J. Amato
AU - AUTHOR GROUP
AU - Sabbe, Martine
AU - Detcheva, Antoaneta
AU - Georgieva, Teodora
AU - Bagatzouni, Despo Pieridou
AU - Køížová, Pavla
AU - Valentiner-Branth, Palle
AU - Fenoll, Asunción
AU - Virolainen-Julkunen, Anni
AU - Georgakopoulou, Theano
AU - Tzanakaki, Georgina
AU - Melles, Márta
AU - Vickers, Imelda
AU - Cotter, Suzanne
AU - Humphreys, Hilary
AU - Kristinsson, Karl G.
AU - Caporali, Maria Grazia
AU - D' Ancona, Fortunato Paolo
AU - Iannazzo, Stefania
AU - Pantosti, Annalisa
AU - Galajeva, Jelena
AU - Caruana, Paul
AU - Melillo, Jackie Maistre
AU - Fenech, Tanya Melillo
AU - de Melker, Hester
AU - Knol, Mirjam
AU - van der Ende, Arie
AU - Steinbakk, Martin
AU - Vestrheim, Didrik F.
AU - Hryniewicz, Waleria
AU - Kuch, Alicja
AU - Paradowska-Stankiewicz, Iwona
AU - Skoczynska, Anna
AU - Pana, Marina
AU - Henriques-Normak, Birgitta
AU - Kraigher, Alenka
AU - Sočan, Maja
AU - Hupkova, Helena
AU - MacDonald, Eisin
AU - Slack, Mary P. E.
AU - Waight, Pauline A.
PY - 2015
Y1 - 2015
N2 - We studied the possible association between patient age and sex, clinical presentation, Streptococcus pneumoniae serotype, antimicrobial resistance, and death in invasive pneumococcal disease cases reported by 17 European countries during 2010. The study sample comprised 2,921 patients, of whom 56.8% were men and 38.2% were >= 65 years of age. Meningitis occurred in 18.5% of cases. Death was reported in 264 (9.0%) cases. Older age, meningitis, and nonsusceptibility to penicillin were significantly associated with death. Non-pneumococcal conjugate vaccine (PCV) serotypes among children <5 years of age and 7-valent PCV serotypes among persons 5-64 years of age were associated with increased risk for death; among adults >= 65 years of age, risk did not differ by serotype. These findings highlight differences in case-fatality rates between serotypes and age; thus, continued epidemiologic surveillance across all ages is crucial to monitor the long-term effects of PCVs
AB - We studied the possible association between patient age and sex, clinical presentation, Streptococcus pneumoniae serotype, antimicrobial resistance, and death in invasive pneumococcal disease cases reported by 17 European countries during 2010. The study sample comprised 2,921 patients, of whom 56.8% were men and 38.2% were >= 65 years of age. Meningitis occurred in 18.5% of cases. Death was reported in 264 (9.0%) cases. Older age, meningitis, and nonsusceptibility to penicillin were significantly associated with death. Non-pneumococcal conjugate vaccine (PCV) serotypes among children <5 years of age and 7-valent PCV serotypes among persons 5-64 years of age were associated with increased risk for death; among adults >= 65 years of age, risk did not differ by serotype. These findings highlight differences in case-fatality rates between serotypes and age; thus, continued epidemiologic surveillance across all ages is crucial to monitor the long-term effects of PCVs
U2 - https://doi.org/10.3201/eid2103.140634
DO - https://doi.org/10.3201/eid2103.140634
M3 - Article
C2 - 25693604
SN - 1080-6040
VL - 21
SP - 417
EP - 425
JO - Emerging infectious diseases
JF - Emerging infectious diseases
IS - 3
ER -