Risk of second malignancies in long-term survivors of childhood cancer

M. C. Cardous-Ubbink; R. C. Heinen; P. J. M. Bakker; H. van den Berg; F. Oldenburger; H. N. Caron; P. A. Voûte; F. E. van Leeuwen

doi:https://doi.org/10.1016/j.ejca.2006.10.004

Risk of second malignancies in long-term survivors of childhood cancer

M. C. Cardous-Ubbink, R. C. Heinen, P. J. M. Bakker, H. van den Berg, F. Oldenburger, H. N. Caron, P. A. Voûte, F. E. van Leeuwen

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Abstract

INTRODUCTION: Childhood cancer survivors are known to be at increased risk for second malignancies. PATIENTS AND METHODS: The risk of second malignancies was assessed in 1368 5-year survivors of childhood cancer treated in the Emma Children's Hospital AMC in Amsterdam. The median follow-up time was 16.8 years. RESULTS: Sixty two malignancies were observed against 5.4 expected, yielding a standardised incidence ratio (SIR) of 11.2 (95% confidence interval: 8.53-14.4; absolute excess risk: 3.2 per 1000 person-years). New observations were the strongly increased risks of meningiomas (SIR=40) and basal cell carcinomas (SIR=9). Patients whose treatment involved radiotherapy had a 2-fold increased second cancer risk compared to patients with chemotherapy alone. DISCUSSION: The relative risk of second malignancies does not decrease till at least 30 years of follow-up. With aging of the survivor cohort this results in a strong increase of the AER, due to the rising background risk of cancer with age

Original language	English
Pages (from-to)	351-362
Journal	European journal of cancer (Oxford, England
Volume	43
Issue number	2
DOIs	https://doi.org/10.1016/j.ejca.2006.10.004
Publication status	Published - 2007

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https://doi.org/10.1016/j.ejca.2006.10.004

Cite this

@article{6eee26feaa4f4272a744521dd77f43f0,

title = "Risk of second malignancies in long-term survivors of childhood cancer",

abstract = "INTRODUCTION: Childhood cancer survivors are known to be at increased risk for second malignancies. PATIENTS AND METHODS: The risk of second malignancies was assessed in 1368 5-year survivors of childhood cancer treated in the Emma Children's Hospital AMC in Amsterdam. The median follow-up time was 16.8 years. RESULTS: Sixty two malignancies were observed against 5.4 expected, yielding a standardised incidence ratio (SIR) of 11.2 (95% confidence interval: 8.53-14.4; absolute excess risk: 3.2 per 1000 person-years). New observations were the strongly increased risks of meningiomas (SIR=40) and basal cell carcinomas (SIR=9). Patients whose treatment involved radiotherapy had a 2-fold increased second cancer risk compared to patients with chemotherapy alone. DISCUSSION: The relative risk of second malignancies does not decrease till at least 30 years of follow-up. With aging of the survivor cohort this results in a strong increase of the AER, due to the rising background risk of cancer with age",

author = "Cardous-Ubbink, {M. C.} and Heinen, {R. C.} and Bakker, {P. J. M.} and {van den Berg}, H. and F. Oldenburger and Caron, {H. N.} and Vo{\^u}te, {P. A.} and {van Leeuwen}, {F. E.}",

year = "2007",

doi = "https://doi.org/10.1016/j.ejca.2006.10.004",

language = "English",

volume = "43",

pages = "351--362",

journal = "European journal of cancer (Oxford, England",

issn = "0959-8049",

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TY - JOUR

T1 - Risk of second malignancies in long-term survivors of childhood cancer

AU - Cardous-Ubbink, M. C.

AU - Heinen, R. C.

AU - Bakker, P. J. M.

AU - van den Berg, H.

AU - Oldenburger, F.

AU - Caron, H. N.

AU - Voûte, P. A.

AU - van Leeuwen, F. E.

PY - 2007

Y1 - 2007

N2 - INTRODUCTION: Childhood cancer survivors are known to be at increased risk for second malignancies. PATIENTS AND METHODS: The risk of second malignancies was assessed in 1368 5-year survivors of childhood cancer treated in the Emma Children's Hospital AMC in Amsterdam. The median follow-up time was 16.8 years. RESULTS: Sixty two malignancies were observed against 5.4 expected, yielding a standardised incidence ratio (SIR) of 11.2 (95% confidence interval: 8.53-14.4; absolute excess risk: 3.2 per 1000 person-years). New observations were the strongly increased risks of meningiomas (SIR=40) and basal cell carcinomas (SIR=9). Patients whose treatment involved radiotherapy had a 2-fold increased second cancer risk compared to patients with chemotherapy alone. DISCUSSION: The relative risk of second malignancies does not decrease till at least 30 years of follow-up. With aging of the survivor cohort this results in a strong increase of the AER, due to the rising background risk of cancer with age

AB - INTRODUCTION: Childhood cancer survivors are known to be at increased risk for second malignancies. PATIENTS AND METHODS: The risk of second malignancies was assessed in 1368 5-year survivors of childhood cancer treated in the Emma Children's Hospital AMC in Amsterdam. The median follow-up time was 16.8 years. RESULTS: Sixty two malignancies were observed against 5.4 expected, yielding a standardised incidence ratio (SIR) of 11.2 (95% confidence interval: 8.53-14.4; absolute excess risk: 3.2 per 1000 person-years). New observations were the strongly increased risks of meningiomas (SIR=40) and basal cell carcinomas (SIR=9). Patients whose treatment involved radiotherapy had a 2-fold increased second cancer risk compared to patients with chemotherapy alone. DISCUSSION: The relative risk of second malignancies does not decrease till at least 30 years of follow-up. With aging of the survivor cohort this results in a strong increase of the AER, due to the rising background risk of cancer with age

U2 - https://doi.org/10.1016/j.ejca.2006.10.004

DO - https://doi.org/10.1016/j.ejca.2006.10.004

M3 - Article

C2 - 17141498

SN - 0959-8049

VL - 43

SP - 351

EP - 362

JO - European journal of cancer (Oxford, England

JF - European journal of cancer (Oxford, England

IS - 2

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