RNAi suppressors encoded by pathogenic human viruses

Walter de Vries; Ben Berkhout

doi:https://doi.org/10.1016/j.biocel.2008.04.015

RNAi suppressors encoded by pathogenic human viruses

Walter de Vries, Ben Berkhout

Medical Microbiology and Infection Prevention (AMC)

Research output: Contribution to journal › Article › Academic › peer-review

63 Citations (Scopus)

Abstract

RNA silencing or RNAi interference (RNAi) serves as an innate antiviral mechanism in plants, fungi and animals. Human viruses, like plant viruses, encode suppressor proteins or RNAs that block or modulate the RNAi pathway. This review summarizes the mechanisms by which pathogenic human viruses affect the RNAi pathway. Furthermore, some applications of the viral RNAi suppressor functions and the consequences for antiviral therapeutic strategies that are based on RNAi are discussed

Original language	English
Pages (from-to)	2007-2012
Journal	International Journal of Biochemistry & Cell Biology
Volume	40
Issue number	10
DOIs	https://doi.org/10.1016/j.biocel.2008.04.015
Publication status	Published - 2008

Access to Document

https://doi.org/10.1016/j.biocel.2008.04.015

Cite this

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title = "RNAi suppressors encoded by pathogenic human viruses",

abstract = "RNA silencing or RNAi interference (RNAi) serves as an innate antiviral mechanism in plants, fungi and animals. Human viruses, like plant viruses, encode suppressor proteins or RNAs that block or modulate the RNAi pathway. This review summarizes the mechanisms by which pathogenic human viruses affect the RNAi pathway. Furthermore, some applications of the viral RNAi suppressor functions and the consequences for antiviral therapeutic strategies that are based on RNAi are discussed",

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AB - RNA silencing or RNAi interference (RNAi) serves as an innate antiviral mechanism in plants, fungi and animals. Human viruses, like plant viruses, encode suppressor proteins or RNAs that block or modulate the RNAi pathway. This review summarizes the mechanisms by which pathogenic human viruses affect the RNAi pathway. Furthermore, some applications of the viral RNAi suppressor functions and the consequences for antiviral therapeutic strategies that are based on RNAi are discussed

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DO - https://doi.org/10.1016/j.biocel.2008.04.015

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