Role of plaque inflammation in acute and recurrent coronary syndromes

M Meuwissen, A C van der Wal, M Siebes, K T Koch, S A J Chamuleau, C M van der Loos, P Teeling, R J de Winter, H W M Niessen, J G P Tijssen, A E Becker, J J Piek

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Inflammation plays an important role in the initiation, development, progression and complications of atherosclerotic vascular disease. Our present knowledge of the elementary role of inflammation for the onset of plaque rupture in atherosclerotic coronary lesions primarily stems from autopsy studies. However, the introduction of directional coronary atherectomy catheters has provided a unique opportunity to directly investigate the role of inflammation in coronary syndromes. In this report we describe the role of coronary plaque inflammation, as determined by immunohistochemistry, on the presentation of coronary syndromes and on the clinical outcome following percutaneous interventions.

Original languageEnglish
Pages (from-to)106-109
Number of pages4
JournalNetherlands heart journal
Issue number3
Publication statusPublished - Mar 2004


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