Role of speckles in laser Doppler perfusion imaging: An investigation on particle suspensions

Vinayakrishnan Rajan; Babu Varghese; Ton G. Van Leeuwen; Wiendelt Steenbergen

doi:https://doi.org/10.1117/12.661601

Role of speckles in laser Doppler perfusion imaging: An investigation on particle suspensions

Vinayakrishnan Rajan, Babu Varghese, Ton G. Van Leeuwen, Wiendelt Steenbergen

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

1 Citation (Scopus)

Abstract

We show that speckles play an important role in laser Doppler perfusion imaging. The influence of speckles on the signal amplitude and the Doppler spectrum is demonstrated experimentally on particle suspensions with different scattering levels and varying beam width. Polystyrene microsphere suspensions with known optical properties are used to make scattering samples. A theoretical model is explained to calculate the speckle size from the back scattered intensity distributions. The coherence area is calculated with Monte Carlo simulations on different scattering samples and experiments are performed to validate our theoretical model. The experimental results are in good agreement with our theoretical predictions.

Original language	English
Title of host publication	Biophotonics and New Therapy Frontiers
DOIs	https://doi.org/10.1117/12.661601
Publication status	Published - 2006
Event	Biophotonics and New Therapy Frontiers - Strasbourg, France Duration: 3 Apr 2006 → 5 Apr 2006

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	6191

Conference

Conference	Biophotonics and New Therapy Frontiers
Country/Territory	France
City	Strasbourg
Period	3/04/2006 → 5/04/2006

Keywords

Back-scattered photons
Laser doppler perfusion imaging
Polystyrene microspheres
Speckles

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https://doi.org/10.1117/12.661601

Cite this

@inproceedings{48599c04c1684e28ba80f474e6d2e2ef,

title = "Role of speckles in laser Doppler perfusion imaging: An investigation on particle suspensions",

abstract = "We show that speckles play an important role in laser Doppler perfusion imaging. The influence of speckles on the signal amplitude and the Doppler spectrum is demonstrated experimentally on particle suspensions with different scattering levels and varying beam width. Polystyrene microsphere suspensions with known optical properties are used to make scattering samples. A theoretical model is explained to calculate the speckle size from the back scattered intensity distributions. The coherence area is calculated with Monte Carlo simulations on different scattering samples and experiments are performed to validate our theoretical model. The experimental results are in good agreement with our theoretical predictions.",

keywords = "Back-scattered photons, Laser doppler perfusion imaging, Polystyrene microspheres, Speckles",

author = "Vinayakrishnan Rajan and Babu Varghese and {Van Leeuwen}, {Ton G.} and Wiendelt Steenbergen",

year = "2006",

doi = "https://doi.org/10.1117/12.661601",

language = "English",

isbn = "0819462470",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

booktitle = "Biophotonics and New Therapy Frontiers",

note = "Biophotonics and New Therapy Frontiers ; Conference date: 03-04-2006 Through 05-04-2006",

}

Rajan, V, Varghese, B, Van Leeuwen, TG & Steenbergen, W 2006, Role of speckles in laser Doppler perfusion imaging: An investigation on particle suspensions. in Biophotonics and New Therapy Frontiers., 619113, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 6191, Biophotonics and New Therapy Frontiers, Strasbourg, France, 3/04/2006. https://doi.org/10.1117/12.661601

Role of speckles in laser Doppler perfusion imaging: An investigation on particle suspensions. / Rajan, Vinayakrishnan; Varghese, Babu; Van Leeuwen, Ton G. et al.
Biophotonics and New Therapy Frontiers. 2006. 619113 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6191).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

TY - GEN

T1 - Role of speckles in laser Doppler perfusion imaging

T2 - Biophotonics and New Therapy Frontiers

AU - Rajan, Vinayakrishnan

AU - Varghese, Babu

AU - Van Leeuwen, Ton G.

AU - Steenbergen, Wiendelt

PY - 2006

Y1 - 2006

N2 - We show that speckles play an important role in laser Doppler perfusion imaging. The influence of speckles on the signal amplitude and the Doppler spectrum is demonstrated experimentally on particle suspensions with different scattering levels and varying beam width. Polystyrene microsphere suspensions with known optical properties are used to make scattering samples. A theoretical model is explained to calculate the speckle size from the back scattered intensity distributions. The coherence area is calculated with Monte Carlo simulations on different scattering samples and experiments are performed to validate our theoretical model. The experimental results are in good agreement with our theoretical predictions.

AB - We show that speckles play an important role in laser Doppler perfusion imaging. The influence of speckles on the signal amplitude and the Doppler spectrum is demonstrated experimentally on particle suspensions with different scattering levels and varying beam width. Polystyrene microsphere suspensions with known optical properties are used to make scattering samples. A theoretical model is explained to calculate the speckle size from the back scattered intensity distributions. The coherence area is calculated with Monte Carlo simulations on different scattering samples and experiments are performed to validate our theoretical model. The experimental results are in good agreement with our theoretical predictions.

KW - Back-scattered photons

KW - Laser doppler perfusion imaging

KW - Polystyrene microspheres

KW - Speckles

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U2 - https://doi.org/10.1117/12.661601

DO - https://doi.org/10.1117/12.661601

M3 - Conference contribution

SN - 0819462470

SN - 9780819462473

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Biophotonics and New Therapy Frontiers

Y2 - 3 April 2006 through 5 April 2006

ER -

Role of speckles in laser Doppler perfusion imaging: An investigation on particle suspensions

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Publication series

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Keywords

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