TY - JOUR
T1 - Role of the striatal dopamine, GABA and opioid systems in mediating feeding and fat intake
AU - Joshi, Anil
AU - Schott, Marion
AU - la Fleur, Susanne Eva
AU - Barrot, Michel
N1 - Funding Information: This work was supported by a doctoral fellowship from the Neurotime Erasmus Mundus Program ( FP7, EU ), by the University of Strasbourg and the CNRS (Centre National de la Recherche Scientifique, France, contract UPR3212 ), the Agence Nationale de la Recherche (France, ANR-15-CE37-0005-02 ; Euridol ANR-17-EURE-0022 ), and by the Netherlands Organization of Scientific Research under Grant Nederlandse Organisatie voor Wetenschappelijk Onderzoek NWO-VICI (Netherlands, grant 016.160.617 ). Publisher Copyright: © 2022 Elsevier Ltd
PY - 2022/8/1
Y1 - 2022/8/1
N2 - Food intake, which is a highly reinforcing behavior, provides nutrients required for survival in all animals. However, when fat and sugar consumption goes beyond the daily needs, it can favor obesity. The prevalence and severity of this health problem has been increasing with time. Besides covering nutrient and energy needs, food and in particular its highly palatable components, such as fats, also induce feelings of joy and pleasure. Experimental evidence supports a role of the striatal complex and of the mesolimbic dopamine system in both feeding and food-related reward processing, with the nucleus accumbens as a key target for reward or reinforcing-associated signaling during food intake behavior. In this review, we provide insights concerning the impact of feeding, including fat intake, on different types of receptors and neurotransmitters present in the striatal complex. Reciprocally, we also cover the evidence for a modulation of palatable food intake by different neurochemical systems in the striatal complex and in particular the nucleus accumbens, with a focus on dopamine, GABA and the opioid system.
AB - Food intake, which is a highly reinforcing behavior, provides nutrients required for survival in all animals. However, when fat and sugar consumption goes beyond the daily needs, it can favor obesity. The prevalence and severity of this health problem has been increasing with time. Besides covering nutrient and energy needs, food and in particular its highly palatable components, such as fats, also induce feelings of joy and pleasure. Experimental evidence supports a role of the striatal complex and of the mesolimbic dopamine system in both feeding and food-related reward processing, with the nucleus accumbens as a key target for reward or reinforcing-associated signaling during food intake behavior. In this review, we provide insights concerning the impact of feeding, including fat intake, on different types of receptors and neurotransmitters present in the striatal complex. Reciprocally, we also cover the evidence for a modulation of palatable food intake by different neurochemical systems in the striatal complex and in particular the nucleus accumbens, with a focus on dopamine, GABA and the opioid system.
KW - Dopamine
KW - GABA
KW - Nucleus accumbens
KW - Obesity
KW - Opioids
KW - Palatable food
UR - http://www.scopus.com/inward/record.url?scp=85132761544&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.neubiorev.2022.104726
DO - https://doi.org/10.1016/j.neubiorev.2022.104726
M3 - Review article
C2 - 35691472
SN - 0149-7634
VL - 139
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
M1 - 104726
ER -