TY - JOUR
T1 - Role of vertebral corner inflammation and fat deposition on MRI on syndesmophyte development detected on whole spine low-dose CT scan in radiographic axial spondyloarthritis
AU - Stal, Rosalinde
AU - Baraliakos, Xenofon
AU - van der Heijde, D. sirée
AU - van Gaalen, Floris
AU - Ramiro, Sofia
AU - van den Berg, Rosaline
AU - Reijnierse, Monique
AU - Braun, Juergen
AU - Landewé, Robert
AU - Sepriano, Alexandre
N1 - Funding Information: This work was supported by Reuma Nederland and Novartis. Funding Information: AS reports consulting fees from UCB, payment from Novartis and support for attending meetings from Lilly and UCB; DvdH reports financial support from the Dutch Rheumatism Association for the Sensitive Imaging in Ankylosing Spondylitis Study, consulting fees from AbbVie, Gilead, GlaxoSmithKline, Lilly, Novartis and UCB and is a Director of Imaging Rheumatology BV; FAvG reports grants from Stichting Vrienden van Sole Mio, Stichting ASAS, Jacobus Stichting, Novartis and UCB, fees from Novartis and personal fees from MSD, AbbVie, Bristol Myers Squibb and Eli-Lilly; MR reports grants for the ASAS CLASSIC Study, outside the submitted work; RL reports consulting fees and speaker honoraria from AbbVie, Amgen, BMS, GSK, Janssen, Eli-Lilly, Novartis, Pfizer and UCB, participation on the data safety monitoring board for a trial outside the submitted work and is a Chair of Quality of Care for EULAR; SR reports grants from AbbVie, Galapagos, MSD, Novartis, Pfizer and UCB, consulting fees from AbbVie, Eli Lilly, MSD, Novartis, Pfizer, UCB and Sanofi and payment/honoraria for lectures/presentations from Eli Lilly, MSD, Novartis and UCB. Publisher Copyright: © 2022 BMJ Publishing Group. All rights reserved.
PY - 2022/7/1
Y1 - 2022/7/1
N2 - Objectives To investigate the associations between MRI detected vertebral corner inflammation (VCI) and vertebral corner fat deposition (VCFD) on whole spine low-dose CT scan (ldCT) detected syndesmophyte formation and growth. Methods Patients from the Sensitive Imaging in Ankylosing Spondylitis cohort underwent MRI (baseline, 1 year and 2 years) and ldCT (baseline and 2 years). MR images were scored by three readers for VCI and VCFD, MRI patterns were defined by presence of VCI and/or VCFD over 2 years. LdCT images were scored by two central readers for presence and size of syndesmophytes and change was calculated for new or new/grown syndesmophytes. Multilevel generalised estimated equations were used to test the associations between VCI and VCFD and syndesmophyte development. Results Fifty radiographic patients with axial spondyloarthritis were included (mean age 49 years, 86% male, 78% HLA-B27+). Absence of both VCI and VCFD protected against syndesmophyte development (ORs 0.36-0.37). Presence of VCI and/or VCFD increased the risk of syndesmophyte development (ORs 1.73-2.60). Out of all corners with a new or new/grown syndesmophyte, 47% of corners according to reader 1 and 44% according to reader 2 had neither VCI nor VCFD preceding the bone formation. Conclusions VCI and VCFD were positively associated with syndesmophyte development. This has been shown for the first time for syndesmophytes detected on ldCT and also in the thoracic spine. However, almost half of all bone formation occurred in corners without VCI or VCFD, suggesting the presence of these lesions in yearly MRIs does not fully clarify the development of syndesmophytes.
AB - Objectives To investigate the associations between MRI detected vertebral corner inflammation (VCI) and vertebral corner fat deposition (VCFD) on whole spine low-dose CT scan (ldCT) detected syndesmophyte formation and growth. Methods Patients from the Sensitive Imaging in Ankylosing Spondylitis cohort underwent MRI (baseline, 1 year and 2 years) and ldCT (baseline and 2 years). MR images were scored by three readers for VCI and VCFD, MRI patterns were defined by presence of VCI and/or VCFD over 2 years. LdCT images were scored by two central readers for presence and size of syndesmophytes and change was calculated for new or new/grown syndesmophytes. Multilevel generalised estimated equations were used to test the associations between VCI and VCFD and syndesmophyte development. Results Fifty radiographic patients with axial spondyloarthritis were included (mean age 49 years, 86% male, 78% HLA-B27+). Absence of both VCI and VCFD protected against syndesmophyte development (ORs 0.36-0.37). Presence of VCI and/or VCFD increased the risk of syndesmophyte development (ORs 1.73-2.60). Out of all corners with a new or new/grown syndesmophyte, 47% of corners according to reader 1 and 44% according to reader 2 had neither VCI nor VCFD preceding the bone formation. Conclusions VCI and VCFD were positively associated with syndesmophyte development. This has been shown for the first time for syndesmophytes detected on ldCT and also in the thoracic spine. However, almost half of all bone formation occurred in corners without VCI or VCFD, suggesting the presence of these lesions in yearly MRIs does not fully clarify the development of syndesmophytes.
KW - inflammation
KW - magnetic resonance imaging
KW - spondylitis, ankylosing
UR - http://www.scopus.com/inward/record.url?scp=85134425962&partnerID=8YFLogxK
U2 - https://doi.org/10.1136/rmdopen-2022-002250
DO - https://doi.org/10.1136/rmdopen-2022-002250
M3 - Article
C2 - 35803614
SN - 2056-5933
VL - 8
JO - RMD OPEN
JF - RMD OPEN
IS - 2
M1 - e002250
ER -