Russell bodies in a skin biopsy: a case report

Joanne Verheij; Elisabeth H Jaspars; Paul van der Valk; Lawrence Rozendaal

doi:https://doi.org/10.1186/1752-1947-3-108

Russell bodies in a skin biopsy: a case report

Joanne Verheij, Elisabeth H Jaspars, Paul van der Valk, Lawrence Rozendaal

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

INTRODUCTION: The presence of eosinophilic bodies in a skin biopsy can be found in a variety of situations and this may present a challenge to the pathologist. The differential diagnosis of these eosinophilic structures include microorganisms such as histoplasmosis or cryptococcosis, fungi, Michaelis-Gutmann bodies, deposits of amyloid or immunoglobulins, colloid bodies or elastic bodies.

CASE PRESENTATION: During a routine examination of a skin biopsy with actinic keratosis taken from the cheek of a 61-year-old man, clusters of eosinophilic bodies were seen within an inflammatory infiltrate in the dermis, both intracytoplasmic and extracellular. Using additional immunohistochemical staining, these structures were identified as polyclonal Russell bodies.

CONCLUSION: The differential diagnosis of intracytoplasmic eosinophilic structures in a skin biopsy includes Russell bodies, an uncommon finding that may be associated with chronic inflammatory conditions.

Original language	English
Article number	108
Pages (from-to)	108
Journal	Journal of Medical Case Reports
Volume	3
DOIs	https://doi.org/10.1186/1752-1947-3-108
Publication status	Published - 4 Nov 2009

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AU - Jaspars, Elisabeth H

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AU - Rozendaal, Lawrence

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AB - INTRODUCTION: The presence of eosinophilic bodies in a skin biopsy can be found in a variety of situations and this may present a challenge to the pathologist. The differential diagnosis of these eosinophilic structures include microorganisms such as histoplasmosis or cryptococcosis, fungi, Michaelis-Gutmann bodies, deposits of amyloid or immunoglobulins, colloid bodies or elastic bodies.CASE PRESENTATION: During a routine examination of a skin biopsy with actinic keratosis taken from the cheek of a 61-year-old man, clusters of eosinophilic bodies were seen within an inflammatory infiltrate in the dermis, both intracytoplasmic and extracellular. Using additional immunohistochemical staining, these structures were identified as polyclonal Russell bodies.CONCLUSION: The differential diagnosis of intracytoplasmic eosinophilic structures in a skin biopsy includes Russell bodies, an uncommon finding that may be associated with chronic inflammatory conditions.

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Russell bodies in a skin biopsy: a case report

Abstract

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