S-nitrosylation of HDAC2 regulates the expression of the chromatin-remodeling factor Brm during radial neuron migration

Alexi Nott; Justyna Nitarska; Jesse V. Veenvliet; Stephan Schacke; Alwin A.H.A. Derijck; Piotr Sirko; Christian Muchardt; R. Jeroen Pasterkamp; Marten P. Smidt; Antonella Riccio

doi:https://doi.org/10.1073/pnas.1218126110

S-nitrosylation of HDAC2 regulates the expression of the chromatin-remodeling factor Brm during radial neuron migration

Alexi Nott, Justyna Nitarska, Jesse V. Veenvliet, Stephan Schacke, Alwin A.H.A. Derijck, Piotr Sirko, Christian Muchardt, R. Jeroen Pasterkamp, Marten P. Smidt, Antonella Riccio

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Dynamic epigenetic modifications play a key role in mediating the expression of genes required for neuronal development. We previously identified nitric oxide (NO) as a signaling molecule that mediates S-nitrosylation of histone deacetylase 2 (HDAC2) and epigenetic changes in neurons. Here, we show that HDAC2 nitrosylation regulates neuronal radial migration during cortical development. Bead-array analysis performed in the developing cortex revealed that brahma (Brm), a subunit of the ATP-dependent chromatin-remodeling complex BRG/brahma-associated factor, is one of the genes regulated by S-nitrosylation of HDAC2. In the cortex, expression of a mutant form of HDAC2 that cannot be nitrosylated dramatically inhibits Brm expression. Our study identifies NO and HDAC2 nitrosylation as part of a signaling pathway that regulates cortical development and the expression of Brm in neurons.

Original language	English
Pages (from-to)	3113-3118
Number of pages	6
Journal	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume	110
Issue number	8
DOIs	https://doi.org/10.1073/pnas.1218126110
Publication status	Published - 19 Feb 2013

Keywords

FNWI top publication
Neural development
Nitric oxide synthase
Polar morphology
Schizophrenia
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https://doi.org/10.1073/pnas.1218126110

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Nott, A., Nitarska, J., Veenvliet, J. V., Schacke, S., Derijck, A. A. H. A., Sirko, P., Muchardt, C., Pasterkamp, R. J., Smidt, M. P., & Riccio, A. (2013). S-nitrosylation of HDAC2 regulates the expression of the chromatin-remodeling factor Brm during radial neuron migration. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(8), 3113-3118. https://doi.org/10.1073/pnas.1218126110

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title = "S-nitrosylation of HDAC2 regulates the expression of the chromatin-remodeling factor Brm during radial neuron migration",

abstract = "Dynamic epigenetic modifications play a key role in mediating the expression of genes required for neuronal development. We previously identified nitric oxide (NO) as a signaling molecule that mediates S-nitrosylation of histone deacetylase 2 (HDAC2) and epigenetic changes in neurons. Here, we show that HDAC2 nitrosylation regulates neuronal radial migration during cortical development. Bead-array analysis performed in the developing cortex revealed that brahma (Brm), a subunit of the ATP-dependent chromatin-remodeling complex BRG/brahma-associated factor, is one of the genes regulated by S-nitrosylation of HDAC2. In the cortex, expression of a mutant form of HDAC2 that cannot be nitrosylated dramatically inhibits Brm expression. Our study identifies NO and HDAC2 nitrosylation as part of a signaling pathway that regulates cortical development and the expression of Brm in neurons.",

keywords = "FNWI top publication, Neural development, Nitric oxide synthase, Polar morphology, Schizophrenia, Transcription",

author = "Alexi Nott and Justyna Nitarska and Veenvliet, {Jesse V.} and Stephan Schacke and Derijck, {Alwin A.H.A.} and Piotr Sirko and Christian Muchardt and Pasterkamp, {R. Jeroen} and Smidt, {Marten P.} and Antonella Riccio",

note = "With supporting information",

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doi = "https://doi.org/10.1073/pnas.1218126110",

language = "English",

volume = "110",

pages = "3113--3118",

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Nott, A, Nitarska, J, Veenvliet, JV, Schacke, S, Derijck, AAHA, Sirko, P, Muchardt, C, Pasterkamp, RJ, Smidt, MP & Riccio, A 2013, 'S-nitrosylation of HDAC2 regulates the expression of the chromatin-remodeling factor Brm during radial neuron migration', PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 110, no. 8, pp. 3113-3118. https://doi.org/10.1073/pnas.1218126110

S-nitrosylation of HDAC2 regulates the expression of the chromatin-remodeling factor Brm during radial neuron migration. / Nott, Alexi; Nitarska, Justyna; Veenvliet, Jesse V. et al.
In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol. 110, No. 8, 19.02.2013, p. 3113-3118.

Research output: Contribution to journal › Article › Academic › peer-review

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T1 - S-nitrosylation of HDAC2 regulates the expression of the chromatin-remodeling factor Brm during radial neuron migration

AU - Nott, Alexi

AU - Nitarska, Justyna

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AU - Schacke, Stephan

AU - Derijck, Alwin A.H.A.

AU - Sirko, Piotr

AU - Muchardt, Christian

AU - Pasterkamp, R. Jeroen

AU - Smidt, Marten P.

AU - Riccio, Antonella

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AB - Dynamic epigenetic modifications play a key role in mediating the expression of genes required for neuronal development. We previously identified nitric oxide (NO) as a signaling molecule that mediates S-nitrosylation of histone deacetylase 2 (HDAC2) and epigenetic changes in neurons. Here, we show that HDAC2 nitrosylation regulates neuronal radial migration during cortical development. Bead-array analysis performed in the developing cortex revealed that brahma (Brm), a subunit of the ATP-dependent chromatin-remodeling complex BRG/brahma-associated factor, is one of the genes regulated by S-nitrosylation of HDAC2. In the cortex, expression of a mutant form of HDAC2 that cannot be nitrosylated dramatically inhibits Brm expression. Our study identifies NO and HDAC2 nitrosylation as part of a signaling pathway that regulates cortical development and the expression of Brm in neurons.

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JF - PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IS - 8

ER -

S-nitrosylation of HDAC2 regulates the expression of the chromatin-remodeling factor Brm during radial neuron migration

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Keywords

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