Safety and tolerability of duloxetine in women with stress urinary incontinence

M. Oelke; J.-P. W. R. Roovers; M. C. Michel

doi:https://doi.org/10.1111/j.1471-0528.2006.00880.x

Safety and tolerability of duloxetine in women with stress urinary incontinence

M. Oelke, J.-P. W. R. Roovers, M. C. Michel

Research output: Contribution to journal › Review article › Academic › peer-review

24 Citations (Scopus)

Abstract

BACKGROUND: The serotonin/noradrenaline uptake inhibitor duloxetine has been shown to be effective in the medical treatment of stress urinary incontinence (SUI) in women. AIM: To review the safety and tolerability of duloxetine with SUI. METHODS: A systematic Medline search for the key word "duloxetine" was performed, and abstracts from recent international gynaecological and urological meetings were also considered. RESULTS: Various unpleasant adverse effects exist, among which nausea is the most frequent, but is mild to moderate and transient in most cases. Dose escalation upon initiation of treatment improves the tolerability of duloxetine. The use of duloxetine appears safe as it lacks the cardiovascular adverse effects of older amine reuptake inhibitors. CONCLUSIONS: Duloxetine has an acceptable safety profile. Dose escalation combined with patient counselling on the intensity and transient nature of adverse effects may help to further improve the benefit/tolerability ratio of duloxetine in the treatment of SUI

Original language	English
Pages (from-to)	22-26
Journal	BJOG
Volume	113
Issue number	Suppl. 1
DOIs	https://doi.org/10.1111/j.1471-0528.2006.00880.x
Publication status	Published - 2006

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https://doi.org/10.1111/j.1471-0528.2006.00880.x

Cite this

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title = "Safety and tolerability of duloxetine in women with stress urinary incontinence",

abstract = "BACKGROUND: The serotonin/noradrenaline uptake inhibitor duloxetine has been shown to be effective in the medical treatment of stress urinary incontinence (SUI) in women. AIM: To review the safety and tolerability of duloxetine with SUI. METHODS: A systematic Medline search for the key word {"}duloxetine{"} was performed, and abstracts from recent international gynaecological and urological meetings were also considered. RESULTS: Various unpleasant adverse effects exist, among which nausea is the most frequent, but is mild to moderate and transient in most cases. Dose escalation upon initiation of treatment improves the tolerability of duloxetine. The use of duloxetine appears safe as it lacks the cardiovascular adverse effects of older amine reuptake inhibitors. CONCLUSIONS: Duloxetine has an acceptable safety profile. Dose escalation combined with patient counselling on the intensity and transient nature of adverse effects may help to further improve the benefit/tolerability ratio of duloxetine in the treatment of SUI",

author = "M. Oelke and Roovers, {J.-P. W. R.} and Michel, {M. C.}",

year = "2006",

doi = "https://doi.org/10.1111/j.1471-0528.2006.00880.x",

language = "English",

volume = "113",

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journal = "BJOG",

issn = "1470-0328",

publisher = "Wiley-Blackwell",

number = "Suppl. 1",

}

TY - JOUR

T1 - Safety and tolerability of duloxetine in women with stress urinary incontinence

AU - Oelke, M.

AU - Roovers, J.-P. W. R.

AU - Michel, M. C.

PY - 2006

Y1 - 2006

N2 - BACKGROUND: The serotonin/noradrenaline uptake inhibitor duloxetine has been shown to be effective in the medical treatment of stress urinary incontinence (SUI) in women. AIM: To review the safety and tolerability of duloxetine with SUI. METHODS: A systematic Medline search for the key word "duloxetine" was performed, and abstracts from recent international gynaecological and urological meetings were also considered. RESULTS: Various unpleasant adverse effects exist, among which nausea is the most frequent, but is mild to moderate and transient in most cases. Dose escalation upon initiation of treatment improves the tolerability of duloxetine. The use of duloxetine appears safe as it lacks the cardiovascular adverse effects of older amine reuptake inhibitors. CONCLUSIONS: Duloxetine has an acceptable safety profile. Dose escalation combined with patient counselling on the intensity and transient nature of adverse effects may help to further improve the benefit/tolerability ratio of duloxetine in the treatment of SUI

AB - BACKGROUND: The serotonin/noradrenaline uptake inhibitor duloxetine has been shown to be effective in the medical treatment of stress urinary incontinence (SUI) in women. AIM: To review the safety and tolerability of duloxetine with SUI. METHODS: A systematic Medline search for the key word "duloxetine" was performed, and abstracts from recent international gynaecological and urological meetings were also considered. RESULTS: Various unpleasant adverse effects exist, among which nausea is the most frequent, but is mild to moderate and transient in most cases. Dose escalation upon initiation of treatment improves the tolerability of duloxetine. The use of duloxetine appears safe as it lacks the cardiovascular adverse effects of older amine reuptake inhibitors. CONCLUSIONS: Duloxetine has an acceptable safety profile. Dose escalation combined with patient counselling on the intensity and transient nature of adverse effects may help to further improve the benefit/tolerability ratio of duloxetine in the treatment of SUI

U2 - https://doi.org/10.1111/j.1471-0528.2006.00880.x

DO - https://doi.org/10.1111/j.1471-0528.2006.00880.x

M3 - Review article

C2 - 16529566

SN - 1470-0328

VL - 113

SP - 22

EP - 26

JO - BJOG

JF - BJOG

IS - Suppl. 1

ER -