Salivary Assessments in Post-Liver Transplantation Patients

Andreea Cristiana Didilescu, Adelina Lazu, Cristian Vlădan, Cristian Scheau, Laura Dan Popa, Petra Șurlin, Wendy Esmeralda Kaman, Hendrik Simon Brand

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1 Citation (Scopus)


Saliva is in the first line of the body’s defense mechanism. In order to better understand how liver transplantation impacts salivary biochemistry, the aim of this cross-sectional study was to explore variations of salivary markers for oral health in post-liver transplantation patients, as compared with systemically healthy dental outpatients (controls). In this case, 26 patients were enrolled in each group, with similar socio-demographic characteristics. Unstimulated whole saliva was collected; total protease activity and total protein content were measured. The oral health in both groups was assessed using a self-report oral health questionnaire. Data were analyzed using parametric and nonparametric tests. Comparable results were recorded in terms of salivary protein and protease activity assessments. In post-liver transplantation group, positive correlation was found between the salivary pH level and the salivary secretion rate (r = 0.39; p = 0.04). With respect to self-reported oral health, there were no significant differences between the two groups, except for dental and oral care habits, the controls reporting more frequently use of dental floss and mouthwash (p = 0.02, and p = 0.003, respectively). Considering the high risk for developing systemic complications after liver transplantation, oral health care is an important issue to be addressed, salivary investigations representing powerful tool for disease changes monitoring.
Original languageEnglish
Article number3152
Pages (from-to)1-12
Number of pages12
JournalClinical Chemistry
Issue number11
Publication statusPublished - 1 Jun 2022


  • liver transplant
  • oral health
  • questionnaire
  • saliva

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