TY - JOUR
T1 - Salivary Function and Oral Health Problems in Crohn's Disease Patients
AU - de Vries, Silvia A G
AU - Tan, Christopher X W
AU - Bouma, Gerd
AU - Forouzanfar, Tim
AU - Brand, Henk S
AU - de Boer, Nanne K
N1 - Publisher Copyright: © 2018 Crohn's & Colitis Foundation. Published by Oxford University Press. All rights reserved.
PY - 2018/5/18
Y1 - 2018/5/18
N2 - Background: In Crohn's disease (CD) patients, many oral complaints have been reported. The aim of this study was to determine whether salivary function is contributing to reduced oral health in CD. Oral and dental complaints in patients were explored. The prevalence of xerostomia in conjunction with salivary flow rates and biochemical saliva composition was studied.Methods: The Xerostomia Inventory score (XI-score), the salivary flow rates, the concentrations of salivary amylase and mucin 5B, and the type of oral and dental complaints were evaluated. These outcomes were stratified by disease activity, using the Harvey Bradshaw Index (HBI) and the Inflammatory Bowel Disease Questionnaire (IBDQ-9).Results: Fifty-three CD patients in a Dutch tertiary referral hospital were included. Of the patients evaluated, 9.4% had hyposalivation under resting conditions, and 28.3% had hyposalivation under chewing stimulated conditions. Saliva secretion rates were not correlated to XI-scores. Median XI-score was 25 (11-45). XI-scores were correlated to the IBDQ scores (r = -0.352, P = 0.010). Salivary mucin 5B was correlated to disease activity (r = 0.295, P = 0.04). Regarding the number of oral complaints, a correlation with disease activity (HBI r = 0.349, P = 0.011) and experienced xerostomia (r = -0.554, P = 0.000) was observed. Oral and dental problems like oral ulcers (37.7%) and cavities (46%) occurred more frequently in CD patients, especially when compared with a non-IBD population.Conclusions: Oral and dental complaints are common in CD patients. Xerostomia is correlated with disease activity-associated quality of life and with the number of oral and dental complaints. Changes in salivary function may contribute to reduced oral health in CD patients. 10.1093/ibd/izy017_video1izy017.video15776803023001.
AB - Background: In Crohn's disease (CD) patients, many oral complaints have been reported. The aim of this study was to determine whether salivary function is contributing to reduced oral health in CD. Oral and dental complaints in patients were explored. The prevalence of xerostomia in conjunction with salivary flow rates and biochemical saliva composition was studied.Methods: The Xerostomia Inventory score (XI-score), the salivary flow rates, the concentrations of salivary amylase and mucin 5B, and the type of oral and dental complaints were evaluated. These outcomes were stratified by disease activity, using the Harvey Bradshaw Index (HBI) and the Inflammatory Bowel Disease Questionnaire (IBDQ-9).Results: Fifty-three CD patients in a Dutch tertiary referral hospital were included. Of the patients evaluated, 9.4% had hyposalivation under resting conditions, and 28.3% had hyposalivation under chewing stimulated conditions. Saliva secretion rates were not correlated to XI-scores. Median XI-score was 25 (11-45). XI-scores were correlated to the IBDQ scores (r = -0.352, P = 0.010). Salivary mucin 5B was correlated to disease activity (r = 0.295, P = 0.04). Regarding the number of oral complaints, a correlation with disease activity (HBI r = 0.349, P = 0.011) and experienced xerostomia (r = -0.554, P = 0.000) was observed. Oral and dental problems like oral ulcers (37.7%) and cavities (46%) occurred more frequently in CD patients, especially when compared with a non-IBD population.Conclusions: Oral and dental complaints are common in CD patients. Xerostomia is correlated with disease activity-associated quality of life and with the number of oral and dental complaints. Changes in salivary function may contribute to reduced oral health in CD patients. 10.1093/ibd/izy017_video1izy017.video15776803023001.
KW - Adult
KW - Crohn Disease/complications
KW - Crohn's disease
KW - Dental Caries/epidemiology
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Mucin-5B/metabolism
KW - Netherlands
KW - Oral Health
KW - Oral Ulcer/epidemiology
KW - Quality of Life
KW - Saliva/metabolism
KW - Salivary Glands/physiopathology
KW - Secretory Rate
KW - Surveys and Questionnaires
KW - Tertiary Care Centers
KW - Xerostomia/etiology
KW - Young Adult
KW - salivary function
UR - http://www.scopus.com/inward/record.url?scp=85047569363&partnerID=8YFLogxK
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85047569363&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/29718221
U2 - https://doi.org/10.1093/ibd/izy017
DO - https://doi.org/10.1093/ibd/izy017
M3 - Article
C2 - 29718221
SN - 1078-0998
VL - 24
SP - 1361
EP - 1367
JO - Inflammatory Bowel Diseases
JF - Inflammatory Bowel Diseases
IS - 6
ER -