TY - JOUR
T1 - Sarcopenia, a strong determinant for prolonged feeding tube dependency after chemoradiotherapy for head and neck cancer
AU - Karsten, R.T.
AU - Al-Mamgani, A.
AU - Bril, S.I.
AU - Tjon-A-Joe, S.
AU - van der Molen, L.
AU - de Boer, J.P.
AU - Hilgers, F.J.M.
AU - Smeele, L.E.
AU - van den Brekel, M.W.M.
AU - Stuiver, M.M.
PY - 2019/11/1
Y1 - 2019/11/1
N2 - Background: Sarcopenia might be a relevant lead for optimization of the condition of patients with head and neck cancer (HNC) before chemoradiotherapy (CRT) to prevent long-term functional swallowing impairment, such as feeding tube dependency. Methods: Regression analyses were performed to assess the association between skeletal muscle mass index (SMI), as a measure of sarcopenia, and prolonged (>90 days) feeding tube dependency in 128 patients with HNC treated with primary CRT. Results: Sixty-one patients (48%) became prolonged feeding tube-dependent. Lower SMI increased the risk of prolonged feeding tube dependency in multivariable analysis (risk ratio 1.08; 95% confidence interval 1.02-1.14, P =.01) adjusted for body mass index, abnormal diet, and socioeconomic status. Conclusions: Sarcopenia contributes to the risk of prolonged feeding tube dependency of patients with HNC treated with primary CRT. As sarcopenia might be a modifiable factor prior to treatment, it should be explored as a target for pretreatment patients' condition.
AB - Background: Sarcopenia might be a relevant lead for optimization of the condition of patients with head and neck cancer (HNC) before chemoradiotherapy (CRT) to prevent long-term functional swallowing impairment, such as feeding tube dependency. Methods: Regression analyses were performed to assess the association between skeletal muscle mass index (SMI), as a measure of sarcopenia, and prolonged (>90 days) feeding tube dependency in 128 patients with HNC treated with primary CRT. Results: Sixty-one patients (48%) became prolonged feeding tube-dependent. Lower SMI increased the risk of prolonged feeding tube dependency in multivariable analysis (risk ratio 1.08; 95% confidence interval 1.02-1.14, P =.01) adjusted for body mass index, abnormal diet, and socioeconomic status. Conclusions: Sarcopenia contributes to the risk of prolonged feeding tube dependency of patients with HNC treated with primary CRT. As sarcopenia might be a modifiable factor prior to treatment, it should be explored as a target for pretreatment patients' condition.
KW - chemoradiotherapy
KW - head and neck cancer
KW - sarcopenia
KW - skeletal muscle mass
KW - tube feeding
UR - http://www.scopus.com/inward/record.url?scp=85071459671&partnerID=8YFLogxK
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85071459671&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/31472000
U2 - https://doi.org/10.1002/hed.25938
DO - https://doi.org/10.1002/hed.25938
M3 - Article
C2 - 31472000
SN - 1043-3074
VL - 41
SP - 4000
EP - 4008
JO - Head and Neck
JF - Head and Neck
IS - 11
ER -