TY - JOUR
T1 - Sarcopenia Is Highly Prevalent in Patients Undergoing Surgery for Gastric Cancer But Not Associated With Worse Outcomes
AU - Tegels, Juul J. W.
AU - van Vugt, Jeroen L. A.
AU - Reisinger, Kostan W.
AU - Hulsewé, Karel W. E.
AU - Hoofwijk, Anton G. M.
AU - Derikx, Joep P. M.
AU - Stoot, Jan H. M. B.
PY - 2015
Y1 - 2015
N2 - Objectives: Aim of this study was to assess the prevalence of sarcopenia and body composition (i.e., subcutaneous and visceral fat) in gastric cancer surgical patients and its association with adverse postoperative outcome. Methods: Preoperative CT scans were obtained from all patients who underwent surgery for gastric adenocarcinoma between January 2005 and September 2012. Total muscle and adipose tissue cross-sectional area were measured at the level of the third lumbar vertebra (L3) transverse processes. Sarcopenia was defined according to gender-and body mass index (BMI)-specific cutoff points. Primary outcome was in-hospital mortality. Secondary outcomes were severe postoperative complications (i.e., Clavien-Dindo classification >= 3a complications) and 6-month mortality. Results: In 152 out of a total of 180 (84.4%) patients, a CT-scan was available for analysis. In total, 86 (57.7%) of the patients were classified as sarcopenic. Sarcopenia was no predictor for in-hospital mortality (P = 0.52), severe complications (P = 1.00) or 6-month mortality (P = 0.69). Intraabdominal and subcutaneous adipose tissue measurements were not associated with in-hospital mortality, severe complications or 6-month mortality. Conclusions: In this population of gastric cancer surgical patients, the prevalence of sarcopenia was 57.7%, which is high compared to other abdominal surgical oncology populations. However, sarcopenia was not associated with postoperative morbidity or mortality. (c) 2015 Wiley Periodicals, Inc
AB - Objectives: Aim of this study was to assess the prevalence of sarcopenia and body composition (i.e., subcutaneous and visceral fat) in gastric cancer surgical patients and its association with adverse postoperative outcome. Methods: Preoperative CT scans were obtained from all patients who underwent surgery for gastric adenocarcinoma between January 2005 and September 2012. Total muscle and adipose tissue cross-sectional area were measured at the level of the third lumbar vertebra (L3) transverse processes. Sarcopenia was defined according to gender-and body mass index (BMI)-specific cutoff points. Primary outcome was in-hospital mortality. Secondary outcomes were severe postoperative complications (i.e., Clavien-Dindo classification >= 3a complications) and 6-month mortality. Results: In 152 out of a total of 180 (84.4%) patients, a CT-scan was available for analysis. In total, 86 (57.7%) of the patients were classified as sarcopenic. Sarcopenia was no predictor for in-hospital mortality (P = 0.52), severe complications (P = 1.00) or 6-month mortality (P = 0.69). Intraabdominal and subcutaneous adipose tissue measurements were not associated with in-hospital mortality, severe complications or 6-month mortality. Conclusions: In this population of gastric cancer surgical patients, the prevalence of sarcopenia was 57.7%, which is high compared to other abdominal surgical oncology populations. However, sarcopenia was not associated with postoperative morbidity or mortality. (c) 2015 Wiley Periodicals, Inc
U2 - https://doi.org/10.1002/jso.24015
DO - https://doi.org/10.1002/jso.24015
M3 - Article
C2 - 26331988
SN - 0022-4790
VL - 112
SP - 403
EP - 407
JO - Journal of surgical oncology
JF - Journal of surgical oncology
IS - 4
ER -