SARS-CoV-2: diagnostic and design conundrums in the context of male factor infertility

Gulam Bahadur; Santanu Acharya; Asif Muneer; Judith Huirne; Mariusz Łukaszuk; Pablo Alexis Doreski; Roy Homburg

doi:https://doi.org/10.1016/j.rbmo.2020.05.014

SARS-CoV-2: diagnostic and design conundrums in the context of male factor infertility

Gulam Bahadur, Santanu Acharya, Asif Muneer, Judith Huirne, Mariusz Łukaszuk, Pablo Alexis Doreski, Roy Homburg

Research output: Contribution to journal › Comment/Letter to the editor › Academic

6 Citations (Scopus)

Abstract

The question of whether SARS-CoV-2 (severe acute respiratory syndrome-related coronavirus-2 [SARS-CoV-2], leading to the COVID-19 infection) can be harboured in the testes and/or semen is currently unanswered. It is essential to understand the limitations of both antibody and real-time PCR tests in interpreting SARS-CoV-2 data in relation to analyses of semen and testicular tissue without appropriate controls. This article critically analyses the evidence so far on this, and the possible implications. The limitations of diagnostic tests in both sampling and testing methodologies, their validation and their relevance in interpreting data are also highlighted.

Original language	English
Journal	Reproductive Biomedicine Online
Early online date	2020
DOIs	https://doi.org/10.1016/j.rbmo.2020.05.014
Publication status	E-pub ahead of print - 2020

Keywords

COVID-19
Diagnosis
Infertility
Male factor
SARS-CoV-2
Semen

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https://doi.org/10.1016/j.rbmo.2020.05.014

Cite this

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title = "SARS-CoV-2: diagnostic and design conundrums in the context of male factor infertility",

abstract = "The question of whether SARS-CoV-2 (severe acute respiratory syndrome-related coronavirus-2 [SARS-CoV-2], leading to the COVID-19 infection) can be harboured in the testes and/or semen is currently unanswered. It is essential to understand the limitations of both antibody and real-time PCR tests in interpreting SARS-CoV-2 data in relation to analyses of semen and testicular tissue without appropriate controls. This article critically analyses the evidence so far on this, and the possible implications. The limitations of diagnostic tests in both sampling and testing methodologies, their validation and their relevance in interpreting data are also highlighted.",

keywords = "COVID-19, Diagnosis, Infertility, Male factor, SARS-CoV-2, Semen",

author = "Gulam Bahadur and Santanu Acharya and Asif Muneer and Judith Huirne and Mariusz {\L}ukaszuk and Doreski, {Pablo Alexis} and Roy Homburg",

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language = "English",

journal = "Reproductive Biomedicine Online",

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T2 - diagnostic and design conundrums in the context of male factor infertility

AU - Bahadur, Gulam

AU - Acharya, Santanu

AU - Muneer, Asif

AU - Huirne, Judith

AU - Łukaszuk, Mariusz

AU - Doreski, Pablo Alexis

AU - Homburg, Roy

PY - 2020

Y1 - 2020

N2 - The question of whether SARS-CoV-2 (severe acute respiratory syndrome-related coronavirus-2 [SARS-CoV-2], leading to the COVID-19 infection) can be harboured in the testes and/or semen is currently unanswered. It is essential to understand the limitations of both antibody and real-time PCR tests in interpreting SARS-CoV-2 data in relation to analyses of semen and testicular tissue without appropriate controls. This article critically analyses the evidence so far on this, and the possible implications. The limitations of diagnostic tests in both sampling and testing methodologies, their validation and their relevance in interpreting data are also highlighted.

AB - The question of whether SARS-CoV-2 (severe acute respiratory syndrome-related coronavirus-2 [SARS-CoV-2], leading to the COVID-19 infection) can be harboured in the testes and/or semen is currently unanswered. It is essential to understand the limitations of both antibody and real-time PCR tests in interpreting SARS-CoV-2 data in relation to analyses of semen and testicular tissue without appropriate controls. This article critically analyses the evidence so far on this, and the possible implications. The limitations of diagnostic tests in both sampling and testing methodologies, their validation and their relevance in interpreting data are also highlighted.

KW - COVID-19

KW - Diagnosis

KW - Infertility

KW - Male factor

KW - SARS-CoV-2

KW - Semen

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U2 - https://doi.org/10.1016/j.rbmo.2020.05.014

DO - https://doi.org/10.1016/j.rbmo.2020.05.014

M3 - Comment/Letter to the editor

C2 - 32565229

SN - 1472-6483

JO - Reproductive Biomedicine Online

JF - Reproductive Biomedicine Online

ER -

SARS-CoV-2: diagnostic and design conundrums in the context of male factor infertility

Abstract

Keywords

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