TY - JOUR
T1 - Schizophrenia risk factors constitute general risk factors for psychiatric symptoms in the population
AU - Breetvelt, Elemi J.
AU - Boks, Marco P. M.
AU - Numans, Mattijs E.
AU - Selten, Jean-Paul
AU - Sommer, Iris E. C.
AU - Grobbee, Diederick E.
AU - Kahn, René S.
AU - Geerlings, Mirjam I.
PY - 2010/7
Y1 - 2010/7
N2 - Background: The presence of a psychosis continuum is suggested by studies showing that schizophrenia and non-clinical psychotic symptoms in the general population share the same risk factors. However, to our knowledge no large-scale studies have been conducted which examine the specificity of these risk factors in the general population. Aim: To investigate whether socio-demographic characteristics associated with non-clinical psychotic symptoms are also associated with other psychiatric symptoms. And secondly, to examine to what extent concomitant psychiatric symptoms explain the relationship between socio-demographic characteristics and non-clinical psychotic symptoms. Methods: In a general population sample of 4894 subjects (mean age 39. years, 45% men) from the Utrecht Health Project we investigated the associations of socio-demographical characteristics with non-clinical psychotic symptoms and other psychiatric symptoms by using the SCL-90. We examined these associations using multivariable logistic regression analyses with and without controlling for the presence of other psychiatric symptoms. Results: Participants with non-clinical psychotic symptoms had an 89% probability of concomitant depressive, anxiety or phobic anxiety symptoms, compared to 11% in participants without psychotic symptoms. The risk profiles for non-clinical psychotic symptoms and other psychiatric symptoms were largely similar. Non-Dutch ethnicity was most strongly associated with non-clinical psychotic symptoms. Adjusting for other psychiatric symptoms did not increase the specificity of the risk factors. Conclusion: Socio-demographic risk factors for non-clinical psychotic symptoms in the general population are also risk factors for other psychiatric symptoms. The relationship between these risk factors and psychotic symptoms are for a substantial part explained by an increase in other psychiatric symptoms. © 2010 Elsevier B.V.
AB - Background: The presence of a psychosis continuum is suggested by studies showing that schizophrenia and non-clinical psychotic symptoms in the general population share the same risk factors. However, to our knowledge no large-scale studies have been conducted which examine the specificity of these risk factors in the general population. Aim: To investigate whether socio-demographic characteristics associated with non-clinical psychotic symptoms are also associated with other psychiatric symptoms. And secondly, to examine to what extent concomitant psychiatric symptoms explain the relationship between socio-demographic characteristics and non-clinical psychotic symptoms. Methods: In a general population sample of 4894 subjects (mean age 39. years, 45% men) from the Utrecht Health Project we investigated the associations of socio-demographical characteristics with non-clinical psychotic symptoms and other psychiatric symptoms by using the SCL-90. We examined these associations using multivariable logistic regression analyses with and without controlling for the presence of other psychiatric symptoms. Results: Participants with non-clinical psychotic symptoms had an 89% probability of concomitant depressive, anxiety or phobic anxiety symptoms, compared to 11% in participants without psychotic symptoms. The risk profiles for non-clinical psychotic symptoms and other psychiatric symptoms were largely similar. Non-Dutch ethnicity was most strongly associated with non-clinical psychotic symptoms. Adjusting for other psychiatric symptoms did not increase the specificity of the risk factors. Conclusion: Socio-demographic risk factors for non-clinical psychotic symptoms in the general population are also risk factors for other psychiatric symptoms. The relationship between these risk factors and psychotic symptoms are for a substantial part explained by an increase in other psychiatric symptoms. © 2010 Elsevier B.V.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77954144227&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/20421160
U2 - https://doi.org/10.1016/j.schres.2010.03.033
DO - https://doi.org/10.1016/j.schres.2010.03.033
M3 - Article
C2 - 20421160
SN - 0920-9964
VL - 120
SP - 184
EP - 190
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 1-3
ER -